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Neurocognitive and endocrine dysfunction in women with exhaustion syndrome
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin. Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper. Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).
2010 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Stress has emerged as one of the most important factors to consider in psychiatric diagnoses and has become a common reason for long-term sick leave (LTSL). Roughly 50% of LTSL due to psychiatric diseases are thought to be associated with work-related stress. The demarcation towards major depression is disputed, and no international consensus exists for how to diagnose and rehabilitate these individuals.

The Swedish National Board of Health has suggested the term “exhaustion syndrome” to integrate these individuals into stress-related disorders. Prominent features of this syndrome are fatigue, sleeping disorders, and cognitive dysfunction. The cognitive dysfunction may be due to an interaction between personality features, environmental factors, the biological effects of stress hormones, and dysfunction in key brain areas, notably the hippocampus and prefrontal cortex. A consistent feature of chronic stress is activation of the cortisol, or hypothalamic-pituitary-adrenal, axis, which may be linked to cognitive dysfunction. Increased glucocorticoid levels, mainly cortisol in humans, are known to impair memory performance. The aim of this thesis was to investigate whether patients with exhaustion syndrome exhibit specific alterations in an extensive set of biological, psychological and immunological variables.

Patients in Study 1 had significant cognitive impairment for specific tasks assumed to tap frontal lobe functioning. In Study 2 anxiety prone, worrying, pessimistic individuals with low executive drive and a persistent personality type were more likely to develop exhaustion syndrome. Decreased reactivity was found on the pituitary level after corticotropin releasing hormone (CRH) in exhaustion syndrome patients. The cortisol/adrenocorticotropic hormone response to CRH was slightly higher in patients compared to controls, indicating increased sensitivity at the adrenal cortex level. No differences were found in hippocampal volume. In Study 3, functional imaging revealed a different pattern of brain activation in working memory tests in patients with exhaustion syndrome compared to healthy individuals and patients with depression.

In summary, our data suggests an intimate link between personality and wellbeing, cognitive performance and neuroendocrine dysfunction, in exhaustion syndrome. We thus find similarities with major depression but also distinct differences between the exhaustion syndrome and major depression.

sted, utgiver, år, opplag, sider
Umeå: Umeå university , 2010. , s. 76
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1379
Emneord [en]
Cognition, attention, working memory, exhaustion syndrome, major depression, cortisol, HPA-axis, proinflammatory cytokines, psychology, neurocognitive, endocrine, fMRI, MRI, prefrontal cortex, multivariate, women, personality, TCI, stress
HSV kategori
Forskningsprogram
medicin; diagnostisk radiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-37280ISBN: 978-91-7459-086-9 (tryckt)OAI: oai:DiVA.org:umu-37280DiVA, id: diva2:358778
Disputas
2010-11-19, Sal B Tandläkarhuset, 901 87 Umeå, Umeå, 09:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2010-10-28 Laget: 2010-10-25 Sist oppdatert: 2018-06-08bibliografisk kontrollert
Delarbeid
1. Impaired cognitive performance in patients with chronic burnout syndrome
Åpne denne publikasjonen i ny fane eller vindu >>Impaired cognitive performance in patients with chronic burnout syndrome
Vise andre…
2005 (engelsk)Inngår i: Biological Psychology, ISSN 0301-0511, E-ISSN 1873-6246, Vol. 69, nr 3, s. 271-279Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Chronic burnout refers to a syndrome caused by chronic stress. Clinical observations indicate that chronic burnout is associated with impaired cognitive functioning. However, there have been no systematic studies of the cognitive performance in chronic burnout patients. We have evaluated general cognitive ability, memory, and attention in 67 female patients treated for chronic burnout. The patients and 15 healthy control subjects were tested with standardized tests of verbal and nonverbal cognitive ability (WAIS), verbal (Claeson–Dahl) and nonverbal (Rey complex figures) memory, and visual and auditory attention (IVA). Significant reductions in nonverbal memory and auditory and visual attention were found for the patient group. These results indicate that patients with chronic burnout have specific cognitive impairments, which should be emphasized in the evaluation of symptoms and treatment regimes in this disorder.

sted, utgiver, år, opplag, sider
Elsevier, 2005
Emneord
Chronic burnout; Stress; Cognition; Memory; Attention; Processing speed
HSV kategori
Forskningsprogram
medicin; psykologi
Identifikatorer
urn:nbn:se:umu:diva-37277 (URN)10.1016/j.biopsycho.2004.08.003 (DOI)15925030 (PubMedID)
Tilgjengelig fra: 2010-10-28 Laget: 2010-10-25 Sist oppdatert: 2018-06-08bibliografisk kontrollert
2. Cognitive deficits in relation to personality type and hypothalamic-pituitary-adrenal (HPA) axis dysfunction in women with stress-related exhaustion
Åpne denne publikasjonen i ny fane eller vindu >>Cognitive deficits in relation to personality type and hypothalamic-pituitary-adrenal (HPA) axis dysfunction in women with stress-related exhaustion
Vise andre…
2011 (engelsk)Inngår i: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 52, nr 1, s. 71-82Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Exhaustion caused by long-term work-related stress may cause cognitive dysfunction. We explored factors that may link chronic stress and cognitive impairment. Personality, psychiatric screening, and behavior were assessed by self-reporting measures in 20 female patients (mean age 39.3 years; range 26–53) with a preliminary diagnosis of stress-related exhaustion and in 16 healthy matched controls. Cognitive performance was investigated with a detailed neuropsychological test battery. Cortisol axis function was assessed by urinary and saliva collections of cortisol, dexamethasone suppression, Synacthen response, and corticotropin-releasing hormone (CRH) tests. Proinflammatory cytokines were measured. Hippocampal volumes were estimated by magnetic resonance imaging. Multivariate and univariate statistical methods were used to explore putative differences between groups and factors linked to cognitive impairment. Cognitive function clearly differed between groups, with decreased attention and visuospatial memory in the patient group, suggesting frontal cortex/medial temporal cortex-network dysfunction. Increased harm avoidance and persistence was present among patients, with lowered self-directedness linked to lower quality of life, increased anxious and depressive tendencies, and experiences of psychosocial stress. Attention was decreased with concomitantly impaired visuospatial memory. The pituitary (adrenocorticotropic hormone, ACTH) response to CRH was decreased in patients, with an increased cortisol/ACTH response to CRH. However, cortisol production rates, diurnal or dexamethasone-suppressed saliva cortisol levels, and the cortisol response to Synacthen were unaltered. Hippocampal volumes did not differ between groups. These findings suggest that cognitive dysfunction in stress-related exhaustion is linked to distinct personality traits, low quality of life, and a decreased ACTH response to CRH.

sted, utgiver, år, opplag, sider
Oxford: Wiley-Blackwell, 2011
Emneord
Stress, personality, cognition, HPA-axis, prefrontal cortex, multivariate analysis.
HSV kategori
Forskningsprogram
diagnostisk radiologi
Identifikatorer
urn:nbn:se:umu:diva-37278 (URN)10.1111/j.1467-9450.2010.00844.x (DOI)20964695 (PubMedID)
Merknad
Titel i avhandling: Stress-related cognitive deficits in relation to personality type and hypothalamic-pituitary-adrenal (HPA) axis dysfunction in womenTilgjengelig fra: 2010-10-28 Laget: 2010-10-25 Sist oppdatert: 2018-06-08bibliografisk kontrollert
3. Brain activation patterns in major depressive disorder and job stress-related long-term sick leave
Åpne denne publikasjonen i ny fane eller vindu >>Brain activation patterns in major depressive disorder and job stress-related long-term sick leave
Vise andre…
(engelsk)Artikkel i tidsskrift (Annet vitenskapelig) Submitted
Identifikatorer
urn:nbn:se:umu:diva-37354 (URN)
Tilgjengelig fra: 2010-10-28 Laget: 2010-10-28 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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