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Sialic acid tissue distribution and influenza virus tropism
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
2008 (engelsk)Inngår i: Influenza and other respiratory viruses, ISSN 1750-2659, Vol. 2, nr 5, s. 147-154Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Avian influenza A viruses exhibit a strong preference for using alpha2,3-linked sialic acid as a receptor. Until recently, the presumed lack of this receptor in human airways was believed to constitute an efficient barrier to avian influenza A virus infection of humans. Recent zoonotic outbreaks of avian influenza A virus have triggered researchers to analyse tissue distribution of sialic acid in further detail. Here, we review and extend the current knowledge about sialic acid distribution in human tissues, and discuss viruses with ocular tropism and their preference for alpha2,3-linked sialic acid.

sted, utgiver, år, opplag, sider
Wiley , 2008. Vol. 2, nr 5, s. 147-154
Emneord [en]
eye, influenza, receptor, sialic acid, tropism
Identifikatorer
URN: urn:nbn:se:umu:diva-41892DOI: 10.1111/j.1750-2659.2008.00051.xPubMedID: 19453419OAI: oai:DiVA.org:umu-41892DiVA, id: diva2:408002
Tilgjengelig fra: 2011-04-01 Laget: 2011-04-01 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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