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Molecular wipes: application to epidemic keratoconjuctivitis
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
Vise andre og tillknytning
2011 (engelsk)Inngår i: Journal of Medicinal Chemistry, ISSN 0022-2623, E-ISSN 1520-4804, Vol. 54, nr 19, s. 6670-6675Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Epidemic keratoconjunctivitis (EKC) is a severe disease of the eye, caused by members of the Adenoviridae (Ad) family, with symptoms such as keratitis, conjunctivitis, pain, edema, and reduced vision that may last for months or years. There are no vaccines or antiviral drugs available to prevent or treat EKC. It was found previously that EKC-causing Ads use sialic acid as a cellular receptor and demonstrated that soluble, sialic acid-containing molecules can prevent infection. In this study, multivalent sialic acid constructs based on 10,12-pentacosadiynoic acid (PDA) have been synthesized, and these constructs are shown to be efficient inhibitors of Ad binding (IC(50) = 0.9 mu M) and Ad infectivity (IC(50) = 0.7 mu M). The mechanism of action is to aggregate virus particles and thereby prevent them from binding to ocular cells. Such formulations may be used for topical treatment of adenovirus-caused EKC.

sted, utgiver, år, opplag, sider
Easton, Pa.: American Chemical Society , 2011. Vol. 54, nr 19, s. 6670-6675
Emneord [en]
sialic acid, colorimetric detection, adenovirus type 37, cellular receptor, potent inhibitors, influenza-virus, keratoconjunctivitis, polymerization, infection, liposomes
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-49226DOI: 10.1021/jm200545mISI: 000295546200022OAI: oai:DiVA.org:umu-49226DiVA, id: diva2:455771
Tilgjengelig fra: 2011-11-11 Laget: 2011-11-04 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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