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Stem cell and neuron co-cultures for the study of nerve regeneration
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB), Anatomi. Blond McIndoe Laboratories, School of Clinical and Laboratory Sciences, University of Manchester, Manchester, UK.
Blond McIndoe Laboratories, School of Clinical and Laboratory Sciences, University of Manchester, Manchester, UK.
Blond McIndoe Laboratories, School of Clinical and Laboratory Sciences, University of Manchester, Manchester, UK.
2011 (engelsk)Inngår i: 3D Cell Culture: Methods and Protocols / [ed] John W. Haycock, New York: Humana Press, 2011, Vol. 695, s. 115-127Kapittel i bok, del av antologi (Fagfellevurdert)
Abstract [en]

Many experimental in vivo studies have indicated that Schwann cells are key facilitators of peripheral nerve regeneration but their clinical therapeutic potential may be limited. Recent advances suggest that stem cell therapy could one day be used to treat nerve traumas. We have shown how adult stem cells can be differentiated into a Schwann cell phenotype, characterised by expression of glial cell proteins and promotion of neurite outgrowth. The development of new cell culture models which mimic the in vivo regeneration environment will help us to better understand the functional benefits of these cells. Here, we describe a stepwise approach towards this, moving from traditional two-dimensional non-contact co-cultures to new three-dimensional models utilising fibrin matrices.

sted, utgiver, år, opplag, sider
New York: Humana Press, 2011. Vol. 695, s. 115-127
Serie
Methods in Molecular Biology, ISSN 1064-3745 ; vol. 695
Emneord [en]
Adult stem cell, Dorsal root ganglia, Fibrin, Glia, Peripheral nerve, Schwann cell, Regeneration
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-54503DOI: 10.1007/978-1-60761-984-0_8PubMedID: 21042969ISBN: 978-1-60761-983-3 (tryckt)ISBN: 978-1-60761-984-0 (tryckt)OAI: oai:DiVA.org:umu-54503DiVA, id: diva2:524058
Tilgjengelig fra: 2012-04-27 Laget: 2012-04-27 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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