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Modulation of Curli Assembly and Pellicle Biofilm Formation by Chemical and Protein Chaperones
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Umeå universitet, Medicinska fakulteten, Umeå Centre for Microbial Research (UCMR).
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Umeå universitet, Medicinska fakulteten, Umeå Centre for Microbial Research (UCMR).
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Umeå universitet, Medicinska fakulteten, Umeå Centre for Microbial Research (UCMR).
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2013 (engelsk)Inngår i: Chemistry and Biology, ISSN 1074-5521, E-ISSN 1879-1301, Vol. 20, nr 10, s. 1245-1254Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Enteric bacteria assemble functional amyloid fibers, curli, on their surfaces that share structural and biochemical properties with disease-associated amyloids. Here, we test rationally designed 2-pyridone compounds for their ability to alter amyloid formation of the major curli subunit CsgA. We identified several compounds that discourage CsgA amyloid formation and several compounds that accelerate CsgA amyloid formation. The ability of inhibitor compounds to stop growing CsgA fibers was compared to the same property of the CsgA chaperone, CsgE. CsgE blocked CsgA amyloid assembly and arrested polymerization when added to actively polymerizing fibers. Additionally, CsgE and the 2-pyridone inhibitors prevented biofilm formation by Escherichia coli at the air-liquid interface of a static culture. We demonstrate that curli amyloid assembly and curli-dependent biofilm formation can be modulated not only by protein chaperones, but also by "chemical chaperones."

sted, utgiver, år, opplag, sider
Elsevier, 2013. Vol. 20, nr 10, s. 1245-1254
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Identifikatorer
URN: urn:nbn:se:umu:diva-82340DOI: 10.1016/j.chembiol.2013.07.017ISI: 000326429400010PubMedID: 24035282OAI: oai:DiVA.org:umu-82340DiVA, id: diva2:660705
Forskningsfinansiär
Swedish Research Council, 2011-6259, 2010-4730Tilgjengelig fra: 2013-10-30 Laget: 2013-10-30 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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Bengtsson, ChristofferChorell, ErikSellstedt, MagnusLindgren, Anders E.G.Wittung-Stafshede, PernillaAlmqvist, Fredrik

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