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N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. (Laboratories for Chemical Biology Umeå, LCBU)
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
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2014 (engelsk)Inngår i: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 58, nr 5, s. 2968-2971Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted pathogen Chlamydia trachomatis. The effect was bactericidal and distinct from that of sulfonamide antibiotics, as para-aminobenzoic acid did not reduce efficacy. Chemical inhibitors play an important role in Chlamydia research as probes of potential targets and as drug development starting points.

sted, utgiver, år, opplag, sider
American Society for Microbiology , 2014. Vol. 58, nr 5, s. 2968-2971
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Identifikatorer
URN: urn:nbn:se:umu:diva-89208DOI: 10.1128/AAC.02015-13ISI: 000334364300064OAI: oai:DiVA.org:umu-89208DiVA, id: diva2:720253
Tilgjengelig fra: 2014-05-28 Laget: 2014-05-26 Sist oppdatert: 2018-06-07bibliografisk kontrollert

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Uvell, HannaSalin, OlliLindgren, Anders E. G.Silver, JimElofsson, MikaelGylfe, Åsa

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