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Molecular perspectives on protein adenylylation
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Dortmund, Germany.
Center for Integrated Protein Science Munich, Chemistry Department, Technische Universität München, Garching, Germany.
2015 (engelsk)Inngår i: ACS Chemical Biology, ISSN 1554-8929, E-ISSN 1554-8937, Vol. 10, nr 1, s. 12-21Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

In the cell, proteins are frequently modified covalently at specific amino acids with post-translational modifications, leading to a diversification of protein functions and activities. Since the introduction of high-resolution mass spectrometry, new post-translational modifications are constantly being discovered. One particular modification is the adenylylation of mammalian proteins. In adenylylation, adenosine triphosphate (ATP) is utilized to attach an adenosine monophosphate at protein threonine or tyrosine residues via a phosphodiester linkage. Adenylylation is particularly interesting in the context of infections by bacterial pathogens during which mammalian proteins are manipulated through AMP attachment via secreted bacterial factors. In this review, we summarize the role and regulation of enzymatic adenylylation and the mechanisms of catalysis. We also refer to recent methods for the detection of adenylylated proteins by modification-specific antibodies, ATP analogues equipped with chemical handles, and mass spectrometry approaches. Additionally, we review screening approaches for inhibiting adenylylation and briefly discuss related modifications such as phosphocholination and phosphorylation.

sted, utgiver, år, opplag, sider
American Chemical Society (ACS), 2015. Vol. 10, nr 1, s. 12-21
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URN: urn:nbn:se:umu:diva-100295DOI: 10.1021/cb500854eISI: 000348332100002PubMedID: 25486069OAI: oai:DiVA.org:umu-100295DiVA, id: diva2:792644
Tilgjengelig fra: 2015-03-04 Laget: 2015-02-27 Sist oppdatert: 2018-06-07bibliografisk kontrollert

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