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Adipose-Derived Stem Cells for Nerve Repair: Hype or Reality?
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB), Anatomi.
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB), Anatomi. Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Handkirurgi.
2014 (engelsk)Inngår i: Cells Tissues Organs, ISSN 1422-6405, E-ISSN 1422-6421, Vol. 200, nr 1, s. 23-30Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Peripheral nerve injury is a relatively commonly occurring trauma which seriously compromises the quality of life for many individuals. There is a major need to devise new treatment strategies, and one possible approach is to develop cellular therapies to bioengineer new nerve tissue and/or modulate the endogenous regenerative mechanisms within the peripheral nervous system. In this short review we describe how stem cells isolated from adipose tissue could be a suitable element of this approach. We describe the possible mechanisms through which the stem cells might exert a positive influence on peripheral nerve regeneration. These include their ability to differentiate into cells resembling Schwann cells and their secretion of a plethora of neurotrophic growth factors. We also review the literature describing the effects of these cells when tested using in vivo peripheral nerve injury models.

sted, utgiver, år, opplag, sider
2014. Vol. 200, nr 1, s. 23-30
Emneord [en]
Differentiation, Growth factors, Nerve regeneration, Schwann cells, Stem cells
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-106167DOI: 10.1159/000369336ISI: 000354830200004PubMedID: 25825218OAI: oai:DiVA.org:umu-106167DiVA, id: diva2:840936
Tilgjengelig fra: 2015-07-09 Laget: 2015-07-09 Sist oppdatert: 2018-06-07bibliografisk kontrollert

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Kingham, Paul J.Wiberg, Mikael

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