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Potential for international spread of wild poliovirus via travelers
Vise andre og tillknytning
2015 (engelsk)Inngår i: BMC Medicine, ISSN 1741-7015, E-ISSN 1741-7015, Vol. 13, artikkel-id 133Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: The endgame of polio eradication is hampered by the international spread of poliovirus via travelers. In response to ongoing importations of poliovirus into polio-free countries, on 5 May 2014, WHO's Director-General declared the international spread of wild poliovirus a public health emergency of international concern. Our objective was to develop a mathematical model to estimate the international spread of polio infections. Methods: Our model took into account polio endemicity in polio-infected countries, population size, polio immunization coverage rates, infectious period, the asymptomatic-to-symptomatic ratio, and also the probability of a traveler being infectious at the time of travel. We applied our model to three scenarios: (1) number of exportations of both symptomatic and asymptomatic polio infections out of currently polio-infected countries, (2) the risk of spread of poliovirus to Saudi Arabia via Hajj pilgrims, and (3) the importation risk of poliovirus into India. Results: Our model estimated 665 polio exportations (>99 % of which were asymptomatic) from nine polio-infected countries in 2014, of which 78.3 % originated from Pakistan. Our model also estimated 21 importations of poliovirus into Saudi Arabia via Hajj pilgrims and 20 poliovirus infections imported to India in the same year. Conclusion: The extent of importations of asymptomatic and symptomatic polio infections is substantial. For countries that are vulnerable to polio outbreaks due to poor national polio immunization coverage rates, our newly developed model may help guide policy-makers to decide whether imposing an entry requirement in terms of proof of vaccination against polio would be justified.

sted, utgiver, år, opplag, sider
2015. Vol. 13, artikkel-id 133
Emneord [en]
Poliomyelitis, Travel, Importation, International spread, Secondary cases, Polio vaccination, India, Hajj lgrimage, Policy, Polio eradication, Mathematical model
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-106330DOI: 10.1186/s12916-015-0363-yISI: 000356483300001OAI: oai:DiVA.org:umu-106330DiVA, id: diva2:842028
Tilgjengelig fra: 2015-07-16 Laget: 2015-07-10 Sist oppdatert: 2018-06-07bibliografisk kontrollert

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Wilder-Smith, AnneliesQuam, Mikkel

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