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Subjective memory impairment in older adults predicts future dementia independent of baseline memory performance: Evidence from the Betula prospective cohort study
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Umeå universitet, Samhällsvetenskapliga fakulteten, Enheten för demografi och åldrandeforskning (CEDAR).
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Psykiatri.ORCID-id: 0000-0002-8114-7615
Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI). Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
2015 (engelsk)Inngår i: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 11, nr 11, s. 1385-1392Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

INTRODUCTION: The objective was to examine whether subjective memory impairment (SMI) predicts all-cause dementia or Alzheimer's disease (AD) in a population-based study with long-term follow-up (median = 10 years).

METHODS: A total of 2043 initially dementia-free participants (≥ 60 years) made three memory ratings ("compared with others", "compared with five years ago", and "complaints from family/friends") at baseline. During follow-up, 372 participants developed dementia (208 with AD).

RESULTS: Cox regression revealed that subjective memory impairment ratings predicted all-cause dementia in models adjusting for age and sex (hazard ratio or HR from 2.04 to 3.94), with even higher values for AD (HR from 2.29 to 5.74). The result persisted in models including other covariates, including baseline episodic memory performance, and in analyses restricted to participants with long time to dementia diagnosis (≥ 5 years).

DISCUSSION: The findings underscore the usefulness of subjective memory assessment in combination with other factors in identifying individuals at risk for developing dementia.

sted, utgiver, år, opplag, sider
2015. Vol. 11, nr 11, s. 1385-1392
Emneord [en]
Subjective memory impairment, Objective memory, Dementia, Alzheimer's disease
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-112734DOI: 10.1016/j.jalz.2014.11.006ISI: 000365162900013PubMedID: 25667997OAI: oai:DiVA.org:umu-112734DiVA, id: diva2:882267
Tilgjengelig fra: 2015-12-14 Laget: 2015-12-14 Sist oppdatert: 2018-06-07bibliografisk kontrollert

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Rönnlund, MichaelSundström, AnnaAdolfsson, RolfNilsson, Lars-Göran

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