umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
miR-129-3p controls centrosome number in metastatic prostate cancer cells by repressing CP110
Vise andre og tillknytning
2016 (engelsk)Inngår i: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 7, nr 13, s. 16676-16687Artikkel i tidsskrift (Fagfellevurdert) Published
Resurstyp
Text
Abstract [en]

The centrosome plays a key role in cancer invasion and metastasis. However, it is unclear how abnormal centrosome numbers are regulated when prostate cancer (PCa) cells become metastatic. CP110 was previously described for its contribution of centrosome amplification (CA) and early development of aggressive cell behaviour. However its regulation in metastatic cells remains unclear. Here we identified miR-129-3p as a novel metastatic microRNA. CP110 was identified as its target protein. In PCa cells that have metastatic capacity, CP110 expression was repressed by miR-129-3p. High miR-129-3p expression levels increased cell invasion, while increasing CP110 levels decreased cell invasion. Overexpression of CP110 in metastatic PCa cells resulted in a decrease in the number of metastasis. In tissues of PCa patients, low CP110 and high miR-129-3p expression levels correlated with metastasis, but not with the expression of genes related to EMT. Furthermore, overexpression of CP110 in metastatic PCa cells resulted in excessive-CA (E-CA), and a change in F-actin distribution which is in agreement with their reduced metastatic capacity. Our data demonstrate that miR-129-3p functions as a CA gatekeeper in metastatic PCa cells by maintaining pro-metastatic centrosome amplification (CA) and preventing anti-metastatic E-CA.

sted, utgiver, år, opplag, sider
2016. Vol. 7, nr 13, s. 16676-16687
Emneord [en]
prostate cancer, centrosome, CP110, miR-129-3p, metastasis
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-121485DOI: 10.18632/oncotarget.7572ISI: 000375692900105PubMedID: 26918338OAI: oai:DiVA.org:umu-121485DiVA, id: diva2:938896
Tilgjengelig fra: 2016-06-17 Laget: 2016-06-02 Sist oppdatert: 2018-06-07bibliografisk kontrollert

Open Access i DiVA

fulltext(5615 kB)186 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 5615 kBChecksum SHA-512
19ca366b3c5fca94b4b0079c8f1acb9759c3557c8c9b9513b92dd88b72e8cb795857f3a704a9a0df3950daa21fd35138e1eba32448151aaa660c972cccb56838
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Nilsson, R. Jonas A.

Søk i DiVA

Av forfatter/redaktør
Nilsson, R. Jonas A.
Av organisasjonen
I samme tidsskrift
OncoTarget

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 186 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 381 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf