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Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
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2016 (engelsk)Inngår i: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 22, nr 37, s. 13004-13009Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

G-quadruplex (G4) structures carry vital biological functions, and compounds that selectively target certain G4 structures have both therapeutic potential and value as research tools. Along this line, 2,2'-diindolylmethanes have been designed and synthesized in this work based on the condensation of 3,6- or 3,7-disubstituted indoles with aldehydes. The developed class of compounds efficiently stabilizes G4 structures without inducing conformational changes in such structures. Furthermore, the 2,2'-diindolylmethanes target certain G4 structures more efficiently than others and this G4 selectivity can be altered by chemical modifications of the compounds.

sted, utgiver, år, opplag, sider
2016. Vol. 22, nr 37, s. 13004-13009
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Identifikatorer
URN: urn:nbn:se:umu:diva-124638DOI: 10.1002/chem.201602416ISI: 000383763200005PubMedID: 27431593OAI: oai:DiVA.org:umu-124638DiVA, id: diva2:953819
Tilgjengelig fra: 2016-08-18 Laget: 2016-08-18 Sist oppdatert: 2018-06-07bibliografisk kontrollert

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Livendahl, MadeleineJamroskovic, JanIvanova, SvetlanaDemirel, PeterSabouri, NasimChorell, Erik

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