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Smokeless tobacco (snus) is associated with an increased risk of type 2 diabetes: results from five pooled cohorts
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2017 (Engelska)Ingår i: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 281, nr 4, s. 398-406Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Smoking and nicotine exposure increase insulin resistance and the risk of type 2 diabetes. Swedish smokeless tobacco (snus) is high in nicotine, and its use is prevalent in Scandinavian countries, but few studies have investigated snus use in relation to diabetes risk.

OBJECTIVE: To explore the association between snus use and risk of type 2 diabetes using pooled data from five cohorts.

METHODS: Analyses were based on prospective studies conducted between 1990 and 2013 including 54 531 never-smoking men and 2441 incident cases of type 2 diabetes identified through screening, self-reporting and hospital and prescription registries. Hazard ratios (HRs) and 95% confidence intervals (CIs) were assessed and adjusted for age, body mass index, educational level, alcohol consumption and physical activity.

RESULTS: Compared to never users, the HR of type 2 diabetes was 1.15 (95% CI: 1.00-1.32) in current users of snus. In individuals consuming 5-6 boxes per week, the HR was 1.42 (95% CI: 1.07-1.87); in those consuming ≥7 boxes per week, the HR was 1.68 (95% CI: 1.17-2.41). Each additional box of snus consumed per week yielded an HR of 1.08 (95% CI: 1.01-1.16).

CONCLUSION: Our findings indicate that high consumption of snus is a risk factor for type 2 diabetes. The risk was similar to that in smokers, implying that smokers will not reduce their risk of type 2 diabetes by changing to snus use. The results also support the notion that nicotine increases the risk of type 2 diabetes.

Ort, förlag, år, upplaga, sidor
2017. Vol. 281, nr 4, s. 398-406
Nyckelord [en]
meta-analysis, public health, tobacco, type 2 diabetes
Nationell ämneskategori
Endokrinologi och diabetes Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-131618DOI: 10.1111/joim.12592ISI: 000397490100006PubMedID: 28164394OAI: oai:DiVA.org:umu-131618DiVA, id: diva2:1075143
Tillgänglig från: 2017-02-17 Skapad: 2017-02-17 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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Norberg, Margareta

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Journal of Internal Medicine
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