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A matter of maturity: the impact of pre-mRNA processing in gene expression and antigen presentation
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi. Équipe Labellisée Ligue Contre le Cancer, Université Paris 7, INSERM UMR 1162, 27 rue Juliette Dodu, 75010 Paris, France; RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
2017 (Engelska)Ingår i: International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, E-ISSN 1878-5875, Vol. 91, s. 203-211Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

RNA processing plays a pivotal role in the diversification of high eukaryotes transcriptome and proteome. The expression of gene products controlling a variety of cellular and physiological processes depends largely on a complex maturation process undergone by pre-mRNAs to become translation-competent mRNAs. Here we review the different mechanisms involved in the pre-mRNA processing and disclose their impact in the gene regulation process in eukaryotic cells. We describe some viral strategies targeting pre-mRNA processing to control gene expression and host immune response and discuss their relevance as tools for a better understanding of cell biology. Finally, we highlight accumulating evidences toward the occurrence of a translation event coupled to mRNA biogenesis in the nuclear compartment and argue how this is relevant for the production of antigenic peptide substrates for the major histocompatibility complex class I pathway.

Ort, förlag, år, upplaga, sidor
2017. Vol. 91, s. 203-211
Nyckelord [en]
pre-mRNA processing, Intronless genes, Nuclear translation, Antigen presentation, Viral infections
Nationell ämneskategori
Biokemi och molekylärbiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-141997DOI: 10.1016/j.biocel.2017.05.023ISI: 000413879500015PubMedID: 28549625OAI: oai:DiVA.org:umu-141997DiVA, id: diva2:1159357
Konferens
1st International Caparica Conference in Splicing (SPLICING), SEP 12-14, 2016, Lisbon, PORTUGAL
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Part: B

Tillgänglig från: 2017-11-22 Skapad: 2017-11-22 Senast uppdaterad: 2019-05-10Bibliografiskt granskad

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Fåhraeus, Robin

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