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Voice Tremor Outcomes of Subthalamic Nucleus and Zona Incerta Deep Brain Stimulation in Patients With Parkinson Disease
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Logopedi.ORCID-id: 0000-0003-3373-0934
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Logopedi.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Öron- näs- och halssjukdomar.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
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2019 (Engelska)Ingår i: Journal of Voice, ISSN 0892-1997, E-ISSN 1873-4588, Vol. 33, nr 4, s. 545-549Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: We aimed to study the effect of deep brain stimulation (DBS) in the subthalamic nucleus (STN) and caudal zona incerta (cZi) on level of perceived voice tremor in patients with Parkinson disease (PD).

Study Design: This is a prospective nonrandomized design with consecutive patients.

Methods: Perceived voice tremor was assessed in patients with PD having received either STN-DBS (8 patients, 5 bilateral and 3 unilateral, aged 43.1-73.6 years; median = 61.2 years) or cZi-DBS (14 bilateral patients, aged 39.0-71.9 years; median = 56.6 years) 12 months before the assessment. Sustained vowels that were produced OFF and ON stimulation (with simultaneous L-DOPA medication) were assessed perceptually in terms of voice tremor by two raters on a four-point rating scale. The assessments were repeated five times per sample and rated in a blinded and randomized procedure.

Results: Three out of the 22 patients (13%) were concluded to have voice tremor OFF stimulation. Patients with PD with STN-DBS showed mild levels of perceived voice tremor OFF stimulation and a group level improvement. Patients with moderate/severe perceived voice tremor and cZi-DBS showed marked improvements, but there was no overall group effect. Six patients with cZi-DBS showed small increases in perceived voice tremor severity.

Conclusions: STN-DBS decreased perceived voice tremor on a group level. cZi-DBS decreased perceived voice tremor in patients with PD with moderate to severe preoperative levels of the symptom.

Ort, förlag, år, upplaga, sidor
Elsevier , 2019. Vol. 33, nr 4, s. 545-549
Nyckelord [en]
DBS; Parkinson disease; STN; Voice tremor; cZi
Nationell ämneskategori
Annan klinisk medicin
Forskningsämne
oto-rhino-laryngologi; neurokirurgi
Identifikatorer
URN: urn:nbn:se:umu:diva-144189DOI: 10.1016/j.jvoice.2017.12.012ISI: 000476489700020PubMedID: 29361338OAI: oai:DiVA.org:umu-144189DiVA, id: diva2:1177310
Forskningsfinansiär
Vetenskapsrådet, 2009-946Tillgänglig från: 2018-01-25 Skapad: 2018-01-25 Senast uppdaterad: 2019-09-06Bibliografiskt granskad

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Karlsson, FredrikMalinova, ElinOlofsson, KatarinaBlomstedt, PatricLinder, JanNordh, Erik

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Karlsson, FredrikMalinova, ElinOlofsson, KatarinaBlomstedt, PatricLinder, JanNordh, Erik
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LogopediÖron- näs- och halssjukdomarKlinisk neurovetenskap
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