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A Study of Dynamic PET Frame-Binning on the Reference Logan Binding Potential
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.ORCID-id: 0000-0002-3353-6501
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Diagnostisk radiologi.
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2017 (Engelska)Ingår i: IEEE Transactions on Radiation and Plasma Medical Sciences, ISSN 2469-7311, Vol. 1, nr 2, s. 128-135Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: The reference Logan plot is a tool for determining the non-displaceable binding potential for dynamic PET exams using tracers with reversible bindings. Dynamic frame protocols affect noise in PET images and short frames can lead to quantitative uncertainties and noise-induced reconstruction bias. The aim of this study was to analyze the effect of frame binning on 11C-Raclopride striatal binding potential from reference Logan analysis. Methods: 12 healthy volunteers were scanned in list mode using 11C-raclopride, and the image data were reconstructed into 9 different frame binning schemes whereof 3 clinical schemes. Reconstruction was performed with 3 different algorithms, one based on filtered back projection (FBP) and two based on ordered subset expectation maximization (OSEM); one including resolution recovery. Logan plots were used for calculating the non-displaceable binding potential. Variation in binding potential was evaluated using Students t-tests. Results: It was found that frame lengths of up to 60 s gave significantly different results compared to the reference clinical protocol for OSEM, both with and without resolution recovery (maximum deviation: 10.3 % for the 15 s protocol). For FBP, frame lengths of up to 30 s gave significantly different results with a maximum deviation of 2.8 %. The higher sampling dependence of OSEM compared to FBP is likely due to noise-dependent bias in the OSEM algorithm, most apparent at high noise levels. Conclusions: Bias related to OSEM reconstruction of high-noise data is an important factor for dynamic PET protocols. Time frames of 120 s or more generate the most stable values for the striatum binding potential with the reference Logan plot for 11C-Raclopride brain PET.

Ort, förlag, år, upplaga, sidor
2017. Vol. 1, nr 2, s. 128-135
Nyckelord [en]
¹¹C-Raclopride, binding potential, dynamic frame protocol, frame binning, Logan analysis, positron emission tomography, time sampling
Nationell ämneskategori
Radiologi och bildbehandling
Identifikatorer
URN: urn:nbn:se:umu:diva-146397DOI: 10.1109/TNS.2016.2639560OAI: oai:DiVA.org:umu-146397DiVA, id: diva2:1196116
Tillgänglig från: 2018-04-09 Skapad: 2018-04-09 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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Wallstén, ElinAxelsson, JanKarlsson, MikaelRiklund, KatrineLarsson, Anne

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Wallstén, ElinAxelsson, JanKarlsson, MikaelRiklund, KatrineLarsson, Anne
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Radiologi och bildbehandling

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