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Cis-Regulatory Mechanisms for Robust Olfactory Sensory Neuron Class-restricted Odorant Receptor Gene Expression in Drosophila
Linköpings universitet, Avdelningen för cellbiologi.
Linköpings universitet, Avdelningen för cellbiologi.
2015 (Engelska)Ingår i: PLoS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 11, nr 3, artikel-id e1005051Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Odor perception requires that each olfactory sensory neuron (OSN) class continuously express a single odorant receptor (OR) regardless of changes in the environment. However, little is known about the control of the robust, class-specific OR expression involved. Here, we investigate the cis-regulatory mechanisms and components that generate robust and OSN class-specific OR expression in Drosophila. Our results demonstrate that the spatial restriction of expression to a single OSN class is directed by clusters of transcription-factor DNA binding motifs. Our dissection of motif clusters of differing complexity demonstrates that structural components such as motif overlap and motif order integrate transcription factor combinations and chromatin status to form a spatially restricted pattern. We further demonstrate that changes in metabolism or temperature perturb the function of complex clusters. We show that the cooperative regulation between motifs around and within the cluster generates robust, class-specific OR expression.

Ort, förlag, år, upplaga, sidor
Public Library of Science , 2015. Vol. 11, nr 3, artikel-id e1005051
Nationell ämneskategori
Klinisk medicin
Identifikatorer
URN: urn:nbn:se:umu:diva-146712DOI: 10.1371/journal.pgen.1005051ISI: 000352197100039PubMedID: 25760344OAI: oai:DiVA.org:umu-146712DiVA, id: diva2:1198582
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Funding Agencies|Swedish Foundation for Strategic Research [F06-0013]; Swedish Research Council [522-2006-6364 / K2007-66P-20436-01-04]

Tillgänglig från: 2018-04-18 Skapad: 2018-04-18 Senast uppdaterad: 2018-12-07Bibliografiskt granskad

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Alenius, Mattias

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