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Regulatory Mechanisms of the Mucin-Like Region on Herpes Simplex Virus during Cellular Attachment
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2019 (Engelska)Ingår i: ACS Chemical Biology, ISSN 1554-8929, E-ISSN 1554-8937, Vol. 14, nr 3, s. 534-542Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Mucin-like regions, characterized by a local high density of O-linked glycosylation, are found on the viral envelope glycoproteins of many viruses. Herpes simplex virus type 1 (HSV-1), for example, exhibits a mucin-like region on its glycoprotein gC, a viral protein involved in initial recruitment of the virus to the cell surface via interaction with sulfated glycosaminoglycans. So far, this mucin-like region has been proposed to play a key role in modulating the interactions with cellular glycosaminoglycans, and in particular to promote release of HSV-1 virions from infected cells. However, the molecular mechanisms and the role as a pathogenicity factor remains unclear. Using single virus particle tracking, we show that the mobility of chondroitin sulfate-bound HSV-1 virions is decreased in absence of the mucin-like region. This decrease in mobility correlates with an increase in HSV-1-chondroitin sulfate binding forces as observed using atomic force microscopy-based force spectroscopy. Our data suggest that the mucin-like region modulates virus-glycosaminoglycan interactions by regulating the affinity, type, and number of glycoproteins involved in the virus glycosaminoglycan interaction. This study therefore presents new evidence for a role of the mucin-like region in balancing the interaction of HSV-1 with glycosaminoglycans and provides further insights into the molecular mechanisms used by the virus to ensure both successful cell entry and release from the infected cell.

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American Chemical Society (ACS), 2019. Vol. 14, nr 3, s. 534-542
Nationell ämneskategori
Cell- och molekylärbiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-157964DOI: 10.1021/acschembio.9b00064ISI: 000461844100026PubMedID: 30735356OAI: oai:DiVA.org:umu-157964DiVA, id: diva2:1305288
Tillgänglig från: 2019-04-16 Skapad: 2019-04-16 Senast uppdaterad: 2019-04-16Bibliografiskt granskad

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Bally, Marta

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Bally, Marta
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Institutionen för klinisk mikrobiologiWallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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