umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Bone formation after implantation of autolyzed antigen-extracted allogeneic bone in ovariectomized rabbits.
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
2003 (Engelska)Ingår i: International Journal of Oral & Maxillofacial Surgery, ISSN 0901-5027, Vol. 32, nr 6, s. 628-632Artikel i tidskrift (Refereegranskat) Published
Ort, förlag, år, upplaga, sidor
2003. Vol. 32, nr 6, s. 628-632
Nationell ämneskategori
Odontologi
Identifikatorer
URN: urn:nbn:se:umu:diva-2605OAI: oai:DiVA.org:umu-2605DiVA, id: diva2:140815
Tillgänglig från: 2003-11-05 Skapad: 2003-11-05 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
Ingår i avhandling
1. Bone Healing after implantation of bone substitute materials. Experimental studies in estrogen deficiency.
Öppna denna publikation i ny flik eller fönster >>Bone Healing after implantation of bone substitute materials. Experimental studies in estrogen deficiency.
2003 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Bone formation and bone healing were studied in the mandible, tibia and skull bones in adult, healthy and estrogen deficient rabbits implanted with different bone substitutes.

In the first study an evaluation of the differences in bone regeneration in and around solid (Alveograf *) and porous hydroxyapatite (Interpore 200*) was undertaken. The implant material was placed into experimentally made bone defects and in half of the defects hydroxyapatite was mixed with a fibrin sealant (Tisseel *). The material alone or mixed with Tisseel was also placed subperiostally in the mandible. The observation time was six month. No difference in bone regeneration was found between solid or porous hydroxyapatite granulas and the addition of Tisseel* did not seem to disturb the bone healing process. The implant material placed subperiostally did not induce bone formation nor did it provoke any bone resorption. The addition of Tisseel made the implant material much easier to handle and retain in the tissue during surgery.

Bone healing around hydroxyapatite implants was also evaluated in the second study. Experimental cavities in the mandible and tibia were filled with hydroxyapatite in granules or blocks (Interpore 200*) but now with or without autolyzed, antigen-extracted, allogeneic bone (AAA). Also in this study Tisseel* was used to facilitate the handling of the material. All cavities implanted with AAA-bone, regardless of the combination with hydroxyapatite or Tisseel, demonstrated excessive bone formation resembling exostosis formation. Thus, hydroxyapatite, both as granules and blocks, can be successfully combined with AAA bone utilizing the bone inductive capacity of AAA bone.

The same model was used to study the healing in ovariectomized animals in the third study. Bone cavities were implanted with or without AAA bone and left to heal. The results indicate that the osteoinductive capacity of AAA bone is in operation also in animals deprived of a normal estrogen production.

The effect of using AAA bone prior to implant insertion was studied in paper four. The bone-implant contact was significant higher when AAA bone had been used. The implant stability did not seem to be affected.

In paper five defects were made in skull and tibial bone in estrogen deficient animals. The deficiency of estrogen was confirmed through blood analysis, the decrease in the weight of uterus and bone mineral density. The whole body scanning with DEXA showed that the ovariectomized animals developed osteopenia. Various degree of bone formation was seen in the defects due to the influence of the bone inductive substance AAA bone.

The studies indicate that a conductive material like hydroxyapatite in granules or blocks could be useful in oral reconstructive surgery. The combination with AAA bone enhanced the bone formation in calvarial and tibial bone in healthy and estrogen deficient animals. Tisseel* could be used to facilitate handling and retention of the material in the intended position during the healing process without negative effects.

Ort, förlag, år, upplaga, sidor
Umeå universitet, 2003. s. 56
Serie
Umeå University odontological dissertations, ISSN 0345-7532 ; 81
Nyckelord
Surgery, Bone grafts, hydroxyapatite, estrogen deficiency, demineralised bone, bone formation, AAA bone, bone defect, titanium implants, resonance frequency analysis., Kirurgi
Nationell ämneskategori
Kirurgi
Forskningsämne
kirurgi
Identifikatorer
urn:nbn:se:umu:diva-138 (URN)91-7305-504-2 (ISBN)
Disputation
2003-11-28, Sal Betula, Byggnad 6 M, Umeå, 09:00
Opponent
Handledare
Tillgänglig från: 2003-11-05 Skapad: 2003-11-05 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

http://dx.doi.org/10.1054/ijom.2003.0428

Personposter BETA

Öberg, Sven

Sök vidare i DiVA

Av författaren/redaktören
Öberg, Sven
Av organisationen
Institutionen för odontologi
Odontologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

urn-nbn

Altmetricpoäng

urn-nbn
Totalt: 70 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf