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Transfer of learning after updating training mediated by the striatum
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Diagnostisk radiologi.
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI). Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
Aging Research Center, Karolinska Institute, 11330 Stockholm, Sweden.
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2008 (Engelska)Ingår i: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 320, nr 5882, s. 1510-1512Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Process-specific training can improve performance on untrained tasks, but the magnitude of gain is variable and often there is no transfer at all. We demonstrate transfer to a 3-back test of working memory after 5 weeks of training in updating. The transfer effect was based on a joint training-related activity increase for the criterion (letter memory) and transfer tasks in a striatal region that also was recruited pretraining. No transfer was observed to a task that did not engage updating and striatal regions, and age-related striatal changes imposed constraints on transfer. These findings indicate that transfer can occur if the criterion and transfer tasks engage specific overlapping processing components and brain regions.

Ort, förlag, år, upplaga, sidor
2008. Vol. 320, nr 5882, s. 1510-1512
Nationell ämneskategori
Medicin och hälsovetenskap Psykologi
Forskningsämne
medicin; psykologi
Identifikatorer
URN: urn:nbn:se:umu:diva-10392DOI: 10.1126/science.1155466OAI: oai:DiVA.org:umu-10392DiVA, id: diva2:150063
Tillgänglig från: 2008-09-03 Skapad: 2008-09-03 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
Ingår i avhandling
1. Train your brain: updating, transfer, and neural changes
Öppna denna publikation i ny flik eller fönster >>Train your brain: updating, transfer, and neural changes
2009 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Alternativ titel[sv]
Träning av hjärnan : uppdatering, transfer effekter, och neurala förändringar
Abstract [en]

An initial aim of this thesis was to determine whether training of a specific executive function (updating) produces improvements in performance on trained and transfer tasks, and whether the effects are maintained over time. Neural systems underlying training and transfer effects were also investigated and one question considered is whether transfer depends on general or specific neural overlap between training and transfer tasks. An additional aim was to identify how individual differences in executive functioning are mapped to functional brain changes. In Study I, significant training-related changes in performance on the letter memory criterion task were found in both young and older adults after 5 weeks of updating training. Transfer to a 3-back test of updating was also demonstrated in the young adults. Functional Magnetic Resonance Imaging (fMRI) revealed overlapping activity in letter memory and 3-back tasks in fronto-parietal areas and striatum pre-training, and a joint training-related activity increase for the tasks in a striatal region. No transfer was observed to a task (Stroop) that engaged fronto-parietal areas, but not the striatal region and updating per se. Moreover, age-related striatal changes imposed constraints on transfer. In Study II, additional transfer tasks and a test of long-term maintenance were included. Results revealed that training-related gains in performance were maintained 18 months post-training in both young and older adults, whereas transfer effects were limited to tasks requiring updating and restricted to young participants. In Study III, analyses of brain activity and performance during n-back (1/2/3-back) were executed. This task enables manipulation of executive demand, which permits examination of how individual differences in executive functioning can be mapped to functional brain changes. Relative to a young high-

performing group, capacity constraints in executive functioning were apparent between 1–2-back for the elderly participants and between 2–3-back for a young low-performing group. Capacity constraints in neural activity followed this pattern by showing a monotonically increasing response in the parietal cortex and the thalamus for young high performers, whereas activity levelled off at 1-back for elderly performers and at 2-back for young low performers. The response in the dorsal frontal cortex followed a similar pattern. Together, these findings indicate that fronto-parietal as well as sub-cortical areas are important for individual differences in executive functioning, training of updating and transfer effects.

Ort, förlag, år, upplaga, sidor
Umeå: Department of Integrative Medical Biology, Section for Physiology, Umeå university, 2009. s. 58
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1283
Nyckelord
cognitive training, executive functioning, transfer, fMRI, brain system, young adults, elderly, practice, neural correlates, individual differences
Nationell ämneskategori
Fysiologi Psykologi (exklusive tillämpad psykologi)
Forskningsämne
fysiologi
Identifikatorer
urn:nbn:se:umu:diva-26606 (URN)978-91-7264-834-0 (ISBN)
Distributör:
Fysiologi, 901 87, Umeå
Disputation
2009-11-13, Biologihuset, BiA201, Umeå Universitet, Umeå, 10:00 (Svenska)
Opponent
Handledare
Tillgänglig från: 2009-10-27 Skapad: 2009-10-16 Senast uppdaterad: 2018-01-12Bibliografiskt granskad

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Dahlin, ErikaStigsdotter-Neely, AnnaLarsson, AnneNyberg, Lars

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Institutionen för integrativ medicinsk biologi (IMB)Diagnostisk radiologiInstitutionen för psykologiUmeå centrum för funktionell hjärnavbildning (UFBI)Radiofysik
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