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Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer
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2011 (Engelska)Ingår i: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 105, nr 9, s. 1458-1464Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: It has been suggested that the relative importance of oestrogen-metabolising pathways may affect the risk of oestrogen-dependent tumours including endometrial cancer. One hypothesis is that the 2-hydroxy pathway is protective, whereas the 16α-hydroxy pathway is harmful.

Methods: We conducted a case-control study nested within three prospective cohorts to assess whether the circulating 2-hydroxyestrone : 16α-hydroxyestrone (2-OHE1 : 16α-OHE1) ratio is inversely associated with endometrial cancer risk in postmenopausal women. A total of 179 cases and 336 controls, matching cases on cohort, age and date of blood donation, were included. Levels of 2-OHE1 and 16α-OHE1 were measured using a monoclonal antibody-based enzyme assay.

Results: Endometrial cancer risk increased with increasing levels of both metabolites, with odds ratios in the top tertiles of 2.4 (95% CI=1.3, 4.6; P(trend)=0.007) for 2-OHE1 and 1.9 (95% CI=1.1, 3.5; P(trend)=0.03) for 16α-OHE1 in analyses adjusting for endometrial cancer risk factors. These associations were attenuated and no longer statistically significant after further adjustment for oestrone or oestradiol levels. No significant association was observed for the 2-OHE1 : 16α-OHE1 ratio.

Conclusion: Our results do not support the hypothesis that greater metabolism of oestrogen via the 2-OH pathway, relative to the 16α-OH pathway, protects against endometrial cancer.

Ort, förlag, år, upplaga, sidor
London: Harcourt Publishers , 2011. Vol. 105, nr 9, s. 1458-1464
Nyckelord [en]
endometrial cancer, nested case–control study, oestrogen metabolites, 2-hydroxyestrone, 16α-hydroxyestrone, post-menopause
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-48717DOI: 10.1038/bjc.2011.381PubMedID: 21952628OAI: oai:DiVA.org:umu-48717DiVA, id: diva2:451910
Tillgänglig från: 2011-10-27 Skapad: 2011-10-27 Senast uppdaterad: 2018-08-31Bibliografiskt granskad

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Idahl, AnnikaOhlson, NinaLenner, PerHallmans, GöranLundin, Eva

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