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Hydrodynamics of the CertasTM programmable valve for the treatment of hydrocephalus
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Neurokirurgi.
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2012 (Engelska)Ingår i: Fluids and barriers of the CNS, ISSN 2045-8118, Vol. 9, nr 1, s. 12-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: The new CertasTM shunt for the treatment of hydrocephalus has seven standard pressure settings that according to the manufacturer range from 36 to 238 mmH2O, and an additional "Virtual Off" setting with an opening pressure >400 mmH2O. Information on actual pressure response and reliability of shunt performance is important in clinical application, especially the "Virtual Off" setting as a non-surgical replacement for shunt ligation. The objective of this study was to evaluate the in-vitro hydrodynamic performance of the CertasTM shunt.

METHODS: Six new CertasTM shunts with proximal and distal catheters were tested with an automated, computerized test system that raised the pressure from zero to a maximum pressure and back to zero at each valve setting. Opening pressure and flow resistance were determined.

RESULTS: For settings 1-7 the measured opening pressure range was 26 to 247 mmH2O, and the mean change in opening pressure for a one-step adjustment was between 33 and 38 mmH2O. For setting 8 ("Virtual Off") the measured mean opening pressure was 494 +/- 34 mmH2O (range 451 to 556 mmH2O). The mean outflow resistance was 7.0 mmHg/ml/min (outflow conductance 17.9 ul/s/kPa).

CONCLUSIONS: The six shunts had similar characteristics and closely matched the manufacturer's specifications for opening pressure at settings 1-7. The opening pressure for the "Virtual Off" setting was nearly 500 mmH2O, which is 100 mmH2O higher than the manufacturer's specification of ">400" and should be functionally off for most patients with communicating hydrocephalus. Clinical studies are needed to evaluate if the CSF dynamic profile persists after implantation in patients.

Ort, förlag, år, upplaga, sidor
2012. Vol. 9, nr 1, s. 12-
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Medicinsk apparatteknik
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URN: urn:nbn:se:umu:diva-55836DOI: 10.1186/2045-8118-9-12PubMedID: 22643114OAI: oai:DiVA.org:umu-55836DiVA, id: diva2:530663
Tillgänglig från: 2012-06-04 Skapad: 2012-06-04 Senast uppdaterad: 2019-11-19Bibliografiskt granskad

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Eklund, AndersKoskinen, Lars-Owe DMalm, Jan

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Eklund, AndersKoskinen, Lars-Owe DMalm, Jan
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RadiofysikNeurokirurgiKlinisk neurovetenskap
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