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Neuronal cells show regulatory differences in the hsp70 gene response.
Department of Anatomy, University of Kuopio, Kuopio, Finland.
Department of Surgery, Kuopio University Hospital, Kuopio, Finland.
Department of Anatomy, University of Kuopio, Kuopio, Finland.
Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland.
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2002 (Engelska)Ingår i: Brain Research. Molecular Brain Research, ISSN 0169-328X, E-ISSN 1872-6941, Vol. 101, nr 1-2, s. 136-140, artikel-id 12007842Artikel i tidskrift (Refereegranskat) Published
Fritextbeskrivning
Abstract [en]

The synthesis of heat shock proteins (Hsps), encoded by heat shock genes, is increased in response to various stress stimuli. Hsps function as molecular chaperones, they dissociate cytotoxic stress-induced protein aggregates within cells and ensure improved survival. Induction of heat shock genes is mainly regulated at the transcriptional level. The stress responsive transcription factor, heat shock factor 1 (HSF1), is involved in the transcriptional induction of the heat shock genes. Our objective was to examine how hsp70 genes are regulated in different transformed and primary neurons upon exposure to elevated temperature. Our findings reveal that the Hsp70 response is regulated at the translational level in Neuro-2a neuroblastoma cells, while the IMR-32 neuroblastoma cells respond to stress by the classical HSF1-driven transcriptional regulatory mechanism. Primary rat hippocampal neurons show a lack of HSF1 and induction of the hsp70 gene. These observations suggest that neuronal cells display different hsp70 gene expression patterns which range from undetected response to transcriptional and posttranscriptional regulation during heat stress.

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Elsevier, 2002. Vol. 101, nr 1-2, s. 136-140, artikel-id 12007842
Nyckelord [en]
Neuronal cells, stress response, hydrostatic pressure, heat shock protein 70
Nationell ämneskategori
Cell- och molekylärbiologi Biokemi och molekylärbiologi Neurovetenskaper
Forskningsämne
biokemi; cellforskning; molekylärbiologi; neurologi
Identifikatorer
URN: urn:nbn:se:umu:diva-107124DOI: 10.1016/S0169-328X(02)00179-1PubMedID: 12007842OAI: oai:DiVA.org:umu-107124DiVA, id: diva2:847078
Tillgänglig från: 2015-08-19 Skapad: 2015-08-19 Senast uppdaterad: 2018-06-07

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Lammi, Mikko

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Brain Research. Molecular Brain Research
Cell- och molekylärbiologiBiokemi och molekylärbiologiNeurovetenskaper

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