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Blood Metabolomic Predictors of 1-Year Outcome in Subarachnoid Hemorrhage
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. (Computational Life Science Cluster, Umeå University, Umeå, Sweden)
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. (Computational Life Science Cluster, Umeå University, Umeå, Sweden)
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2015 (Engelska)Ingår i: Neurocritical Care, ISSN 1541-6933, E-ISSN 1556-0961, Vol. 23, nr 2, s. 225-232Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Delayed neurological deficit (DND) is the most important cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) whose aneurysms have been secured. However, the methods currently used to predict the development of DND, such as trans-cranial Doppler or levels biochemical markers in blood and cerebrospinal fluid are not very accurate. Venous blood was drawn from 50 patients with SAH, admitted to the neurosurgical department UmeAyen University Hospital, at day 1-3 and day 7 after the bleed. The clinical status of the patients was followed up approximately 1 year after this episode and classified according to the Glasgow Outcome Score (GOS). Results showed considerable differences in blood metabolomic patterns between day 1-3 and 7 after the hemorrhage. Fifty-six out of 98 metabolites could be identified from our in-house library and 17 of these metabolites changed significantly from day 1-3 to 7 after the bleed. One of these, myo-inositol, was predictive of clinical outcome even after correction for multiple testing. An estimation of the diagnostic accuracy of high levels of this substance in predicting good outcome (GOS 4-5) yielded a sensitivity of .763 and a specificity of .5 at the optimal cut off point. SAH is an event with a profound effect on blood metabolomics profiles. Myo-inositol might be an interesting compound for future study to focus on in the search for metabolic markers in venous blood of delayed neurological deterioration in SAH patients.

Ort, förlag, år, upplaga, sidor
Springer, 2015. Vol. 23, nr 2, s. 225-232
Nyckelord [en]
Delayed neurological deficit, Myo-inositol, Metabolomics, Subarachnoid hemorrhage, Vasospasm, nous blood
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-109362DOI: 10.1007/s12028-014-0089-2ISI: 000360700700012PubMedID: 25667130OAI: oai:DiVA.org:umu-109362DiVA, id: diva2:857993
Tillgänglig från: 2015-09-30 Skapad: 2015-09-25 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Sjöberg, Rickard L.Bergenheim, TommyMörén, LinaAntti, HenrikLindgren, CeciliaNaredi, SilvanaLindvall, Peter

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Sjöberg, Rickard L.Bergenheim, TommyMörén, LinaAntti, HenrikLindgren, CeciliaNaredi, SilvanaLindvall, Peter
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Klinisk neurovetenskapKemiska institutionenAnestesiologi och intensivvård
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