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A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Göteborg, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
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2015 (Engelska)Ingår i: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 26, nr 6, s. 557-563Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Animal sensitization is a major determinant of asthma in children. Component-resolved studies of unselected pediatric populations are lacking. The aim was to describe sensitization to animal components and the association with asthma and rhinitis in animal-sensitized schoolchildren. Methods: A random sample of 696 children (11-12years) from a Swedish population-based cohort was tested for sensitization to cat, dog, and horse dander using ImmunoCAP. Sera from animal-sensitized children were further analyzed by microarray including three allergen components from cat, four from dog, and two from horse. The parents completed an expanded ISAAC questionnaire. Results: Of 259 animal-sensitized children (0.1 kU(A)/l), 51% were sensitized to all three, 23% to two, and 25% to one species. Current asthma and asthma symptoms following contact with cats were associated with co-sensitization to Fel d 1 and Fel d 4. This association was seen already at moderate-level sensitization (1-15 ISU) to Fel d 4, at which level most children were sensitized to Fel d 1, as well. In dog-sensitized children, the majority was sensitized to more than one dog component, and co-sensitization to Can f 5 and Can f 1/f 2 conferred the greatest risk for asthma. Sensitization to the highly cross-reactive serum albumins was uncommon and not associated with asthma. Conclusions: Among schoolchildren in northern Sweden, where mite allergy is uncommon, furry animals were the primary perennial sensitizers. Asthma was associated with higher levels of component sensitization, and sensitization to more than one component from the same animal conferred the greatest risk.

Ort, förlag, år, upplaga, sidor
Wiley-Blackwell, 2015. Vol. 26, nr 6, s. 557-563
Nyckelord [en]
children, allergy, furry animals, allergen components, component-resolved diagnosis, asthma, rhinitis
Nationell ämneskategori
Immunologi inom det medicinska området Pediatrik
Identifikatorer
URN: urn:nbn:se:umu:diva-109914DOI: 10.1111/pai.12422ISI: 000361476700011PubMedID: 26059105OAI: oai:DiVA.org:umu-109914DiVA, id: diva2:860951
Tillgänglig från: 2015-10-14 Skapad: 2015-10-09 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Bjerg, AndersWinberg, AnnaRönmark, Eva

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Immunologi inom det medicinska områdetPediatrik

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