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Hyaluronan stimulates keratinocyte migration and activates the transcription factor AP-1 in keratinocytes through the JNK pathway
Department of Anatomy, University of Kuopio, Kuopio, Finland.
Department of Anatomy, University of Kuopio, Kuopio, Finland.
Department of Anatomy, University of Kuopio, Kuopio, Finland.
Department of Anatomy, University of Kuopio, Kuopio, Finland.
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2002 (Engelska)Ingår i: Hyaluronan, Vol 1: Chemical, Biochemical and Biological Aspects / [ed] Kennedy JF, Phillips GO, Williams PA, Hascall VC, Great Britain: Woodhead Publishing Limited, 2002, Vol. 1, s. 551-556Konferensbidrag, Publicerat paper (Refereegranskat)
Abstract [en]

Hyaluronan (HA) has been considered a passive extracellular matrix (ECM) polysaccharide, but recent studies have shown its importance in controlling many cell functions including motility, proliferation and adhesion, which imply signaling from ECM to cytosol. Hyaluronan is a major ECM component in stratified epithelia such as skin epidermis. We found that hyaluronan added to the growth medium of newly plated human skin keratinocytes increased cell migration in an in vitro wound-healing assay. Hyaluronan also increased the transcription factor AP-1, as determined by gel shift assays. The kinase signals that apperently led to the increased AP-1 level were associated with the activation of c-Jun, mainly via the JNK pathway as early as 10 min after the addition of hyaluronan, and with the minimum concentration of 10 ng/ml. ERK1 was also slightly activated, while p38 MAPkinase was not affected.

Ort, förlag, år, upplaga, sidor
Great Britain: Woodhead Publishing Limited, 2002. Vol. 1, s. 551-556
Nyckelord [en]
Hyaluronan, AP-1, keratinocyte, Mitogen-activated protein kinase
Nationell ämneskategori
Cell- och molekylärbiologi Biokemi och molekylärbiologi Dermatologi och venereologi
Forskningsämne
biokemi; cellforskning; dermatologi och venereologi
Identifikatorer
URN: urn:nbn:se:umu:diva-111587DOI: 10.1533/9781845693121.551ISBN: 1855735709 (tryckt)OAI: oai:DiVA.org:umu-111587DiVA, id: diva2:871934
Konferens
Hyaluronan 2000
Tillgänglig från: 2015-11-17 Skapad: 2015-11-17 Senast uppdaterad: 2018-06-07

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Lammi, Mikko

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Lammi, Mikko
Cell- och molekylärbiologiBiokemi och molekylärbiologiDermatologi och venereologi

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