umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
miR-129-3p controls centrosome number in metastatic prostate cancer cells by repressing CP110
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 7, nr 13, s. 16676-16687Artikel i tidskrift (Refereegranskat) Published
Resurstyp
Text
Abstract [en]

The centrosome plays a key role in cancer invasion and metastasis. However, it is unclear how abnormal centrosome numbers are regulated when prostate cancer (PCa) cells become metastatic. CP110 was previously described for its contribution of centrosome amplification (CA) and early development of aggressive cell behaviour. However its regulation in metastatic cells remains unclear. Here we identified miR-129-3p as a novel metastatic microRNA. CP110 was identified as its target protein. In PCa cells that have metastatic capacity, CP110 expression was repressed by miR-129-3p. High miR-129-3p expression levels increased cell invasion, while increasing CP110 levels decreased cell invasion. Overexpression of CP110 in metastatic PCa cells resulted in a decrease in the number of metastasis. In tissues of PCa patients, low CP110 and high miR-129-3p expression levels correlated with metastasis, but not with the expression of genes related to EMT. Furthermore, overexpression of CP110 in metastatic PCa cells resulted in excessive-CA (E-CA), and a change in F-actin distribution which is in agreement with their reduced metastatic capacity. Our data demonstrate that miR-129-3p functions as a CA gatekeeper in metastatic PCa cells by maintaining pro-metastatic centrosome amplification (CA) and preventing anti-metastatic E-CA.

Ort, förlag, år, upplaga, sidor
2016. Vol. 7, nr 13, s. 16676-16687
Nyckelord [en]
prostate cancer, centrosome, CP110, miR-129-3p, metastasis
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-121485DOI: 10.18632/oncotarget.7572ISI: 000375692900105PubMedID: 26918338OAI: oai:DiVA.org:umu-121485DiVA, id: diva2:938896
Tillgänglig från: 2016-06-17 Skapad: 2016-06-02 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

Open Access i DiVA

fulltext(5615 kB)187 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 5615 kBChecksumma SHA-512
19ca366b3c5fca94b4b0079c8f1acb9759c3557c8c9b9513b92dd88b72e8cb795857f3a704a9a0df3950daa21fd35138e1eba32448151aaa660c972cccb56838
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Nilsson, R. Jonas A.

Sök vidare i DiVA

Av författaren/redaktören
Nilsson, R. Jonas A.
Av organisationen
Onkologi
I samma tidskrift
OncoTarget
Cancer och onkologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 187 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 381 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf