Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Age-dependent regulation of lipogenesis in human and rat adipocytes.
Department of Pediatrics, Huddinge University Hospital, Huddinge, Sweden.
Department of Pediatrics, Huddinge University Hospital, Huddinge, Sweden.
Department of Surgery, Huddinge University Hospital, Huddinge, Sweden.
Endocrine Research Unit, Huddinge University Hospital, Huddinge, Sweden.
Show others and affiliations
2004 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 89, no 9, p. 4601-4606Article in journal (Refereed) Published
Abstract [en]

The regulation of adipocyte metabolism is of importance for adipose tissue growth and therefore also for the development of obesity. This study was designed to investigate the regulation of basal and insulin-induced lipogenesis, glucose transport, and glucose transporter protein expression in human and rat adipocytes from different age groups. The study included 21 infants, 21 children, nine adults, and 80 male weaned and 20 male adult Fischer rats. The lipogenesis experiments were performed under conditions at which glucose transport is rate limiting. Basal lipogenesis was approximately three times higher in infants and children than in adults, whereas insulin-induced lipogenesis was two times higher in infants than in children and adults. In rats, basal lipogenesis, insulin-induced lipogenesis, and insulin sensitivity were two times higher in weaned than in adult animals. Moreover, basal and insulin-induced glucose transport were two times higher in weaned than in adult rats. No differences were detected in GLUT1 or GLUT4 content between any of the age groups in human or in rat adipocytes. In conclusion, basal and insulin-stimulated lipogenesis are increased in adipocytes early in life. This may promote adipose tissue growth in early age. The data indicate that age-dependent variation in basal and insulin-stimulated lipogenesis is differently regulated.

Place, publisher, year, edition, pages
2004. Vol. 89, no 9, p. 4601-4606
Keywords [en]
Lipogenesis, adipocytes
National Category
Surgery
Identifiers
URN: urn:nbn:se:umu:diva-126913DOI: 10.1210/jc.2003-030994PubMedID: 15356069OAI: oai:DiVA.org:umu-126913DiVA, id: diva2:1038905
Available from: 2016-10-20 Created: 2016-10-20 Last updated: 2018-06-09

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records

Strigård, Karin

Search in DiVA

By author/editor
Strigård, Karin
In the same journal
Journal of Clinical Endocrinology and Metabolism
Surgery

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 113 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf