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HSV presence in brains of individuals without dementia: the TASTY brain series
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
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2016 (engelsk)Inngår i: Disease Models and Mechanisms, ISSN 1754-8403, E-ISSN 1754-8411, Vol. 9, nr 11, s. 1349-1355Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the Tampere Autopsy Study (TASTY) brain samples using PCR and sero-positivity in plasma, and associations with Alzheimer's disease neuropathology. HSV was shown to be present in human brain tissue in 11/584 (1.9%) of samples in the TASTY cohort, of which six had Alzheimer's disease neuropathological amyloid beta (A beta) aggregations. Additionally, serological data revealed 86% of serum samples tested were IgG-positive for HSV. In conclusion, we report epidemiological evidence of the presence of HSV in brain tissue free from encephalitis symptoms in a cohort most closely representing the general population (a minimum prevalence of 1.9%). Whereas 6/11 samples with HSV DNA in the brain tissue had A beta aggregations, most of those with A beta aggregations did not have HSV present in the brain tissue.

sted, utgiver, år, opplag, sider
2016. Vol. 9, nr 11, s. 1349-1355
Emneord [en]
Herpes simplex virus, Amyloid beta aggregations, Alzheimer's disease, PCR detection, Human brain tissue, Paraffin-embedded samples
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-129884DOI: 10.1242/dmm.026674ISI: 000387581000011PubMedID: 27664135OAI: oai:DiVA.org:umu-129884DiVA, id: diva2:1065531
Tilgjengelig fra: 2017-01-16 Laget: 2017-01-10 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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Olsson, JanLövheim, HugoHonkala, EmmaElgh, Fredrik

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