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Dietary inflammatory index and risk of first myocardial infarction: a prospective population-based study
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology. (Arcum)
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research. (Arcum)
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.ORCID iD: 0000-0002-9692-101X
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
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2017 (English)In: Nutrition Journal, E-ISSN 1475-2891, Vol. 16, article id 21Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory index (DII(TM)), which has been associated with cardiovascular disease risk in some previous studies. We aimed to examine the association between the DII and the risk of first myocardial infarction (MI) in a population-based study with long follow-up.

METHOD: We conducted a prospective case-control study of 1389 verified cases of first MI and 5555 matched controls nested within the population-based cohorts of the Northern Sweden Health and Disease Study (NSHDS), of which the largest is the ongoing Västerbotten Intervention Programme (VIP) with nearly 100 000 participants during the study period. Median follow-up from recruitment to MI diagnosis was 6.4 years (6.2 for men and 7.2 for women). DII scores were derived from a validated food frequency questionnaire (FFQ) administered in 1986-2006. Multivariable conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI), using quartile 1 (most anti-inflammatory diet) as the reference category. For validation, general linear models were used to estimate the association between the DII scores and two inflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) in a subset (n = 605) of the study population.

RESULTS: Male participants with the most pro-inflammatory DII scores had an increased risk of MI [ORQ4vsQ1 = 1.57 (95% CI 1.21-2.02) P trend = 0.02], which was essentially unchanged after adjustment for potential confounders, including cardiovascular risk factors [ORQ4vsQ1 = 1.50 (95% CI 1.14-1.99), P trend = 0.10]. No association was found between DII and MI in women. An increase of one DII score unit was associated with 9% higher hsCRP (95% CI 0.03-0.14) and 6% higher IL-6 (95% CI 0.02-0.11) in 605 controls with biomarker data available.

CONCLUSION: A pro-inflammatory diet was associated with an elevated risk of first myocardial infarction in men; whereas for women the relationship was null. Consideration of the inflammatory impact of diet could improve prevention of cardiovascular disease.

Place, publisher, year, edition, pages
BioMed Central, 2017. Vol. 16, article id 21
Keywords [en]
DII Dietary inflammatory index, MI Myocardial infarction, NSHDS Northern Sweden health and disease study, VIP Vasterbotten intervention programme, MONICA Monitoring of trends and determinants in cardiovascular disease, CVD cardiovascular disease, hsCRP high-sensitivity C-reactive protein, IL-6 interleukin 6
National Category
Public Health, Global Health, Social Medicine and Epidemiology Nutrition and Dietetics
Research subject
Public health
Identifiers
URN: urn:nbn:se:umu:diva-133833DOI: 10.1186/s12937-017-0243-8ISI: 000398222800001PubMedID: 28376792Scopus ID: 2-s2.0-85016964521OAI: oai:DiVA.org:umu-133833DiVA, id: diva2:1089064
Note

Publicerad som open source med stöd från Arcums strategiska medel.

Available from: 2017-04-18 Created: 2017-04-18 Last updated: 2024-07-04Bibliographically approved
In thesis
1. Inflammation and risk of chronic diseases with a focus on colorectal cancer and the impact of dietary patterns
Open this publication in new window or tab >>Inflammation and risk of chronic diseases with a focus on colorectal cancer and the impact of dietary patterns
2020 (English)Doctoral thesis, comprehensive summary (Other academic)
Alternative title[sv]
Inflammation och risk för kroniska sjukdomar med fokus på kolorektalcancer och inverkan av kostmönster
Place, publisher, year, edition, pages
Umeå, Sweden: Umeå university, 2020. p. 81
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 2099
Keywords
nutritional epidemiology, dietary patterns, epidemiology, cancer, colorectal cancer, chronic low-grade inflammation, biomarkers, metabolomics, nutritionsepidemiologi, kostmönster, epidemiologi, cancer, kolorektalcancer, kronisk låggradig inflammation, biomarkörer, metabolomik
National Category
Cancer and Oncology Public Health, Global Health, Social Medicine and Epidemiology Nutrition and Dietetics
Research subject
Epidemiology
Identifiers
urn:nbn:se:umu:diva-176737 (URN)978-91-7855-366-2 (ISBN)978-91-7855-365-5 (ISBN)
Public defence
2020-12-11, Hörsal B, Unod T9, Norrlands universitetssjukhus, Umeå, 09:00 (Swedish)
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Available from: 2020-11-20 Created: 2020-11-16 Last updated: 2022-05-12Bibliographically approved

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Bodén, StinaWennberg, MariaVan Guelpen, BethanyJohansson, IngegerdLindahl, BerntNilsson, Lena Maria

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