Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Department of Occupational and Public Health Sciences, University of Gävle, Sweden.ORCID-id: 0000-0003-4088-0025
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: BMJ Open, E-ISSN 2044-6055, Vol. 7, nr 2, artikel-id e013879Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: To investigate the pathophysiological pathways leading to symptoms elicitation in multiple chemical sensitivity (MCS) by comparing gene expression in MCS participants and healthy controls before and after a chemical exposure optimised to cause symptoms among MCS participants. The first hypothesis was that unexposed and symptom=-free MCS participants have similar gene expression patterns to controls and a second hypothesis that MCS participants can be separated from controls based on differential gene expression upon a controlled n=-butanol exposure.

Design: Participants were exposed to 3.7 ppm n-butanol while seated in a windowed exposure chamber for 60 min. A total of 26 genes involved in biochemical pathways found in the literature have been proposed to play a role in the pathogenesis of MCS and other functional somatic syndromes were selected. Expression levels were compared between MCS and controls before, within 15 min after being exposed to and 4 hours after the exposure.

Settings: Participants suffering from MCS and healthy controls were recruited through advertisement at public places and in a local newspaper.

Participants: 36 participants who considered themselves sensitive were prescreened for eligibility. 18 sensitive persons fulfilling the criteria for MCS were enrolled together with 18 healthy controls.

Outcome measures: 17 genes showed sufficient transcriptional level for analysis. Group comparisons were conducted for each gene at the 3 times points and for the computed area under the curve (AUC) expression levels.

Results: MCS participants and controls displayed similar gene expression levels both at baseline and after the exposure and the computed AUC values were likewise comparable between the 2 groups. The intragroup variation in expression levels among MCS participants was noticeably greater than the controls.

Conclusions: MCS participants and controls have similar gene expression levels at baseline and it was not possible to separate MCS participants from controls based on gene expression measured after the exposure.

Ort, förlag, år, upplaga, sidor
2017. Vol. 7, nr 2, artikel-id e013879
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Psykologi
Identifikatorer
URN: urn:nbn:se:umu:diva-133669DOI: 10.1136/bmjopen-2016-013879ISI: 000397872400106PubMedID: 28232466Scopus ID: 2-s2.0-85014036992OAI: oai:DiVA.org:umu-133669DiVA, id: diva2:1090769
Tillgänglig från: 2017-04-25 Skapad: 2017-04-25 Senast uppdaterad: 2023-08-28Bibliografiskt granskad

Open Access i DiVA

fulltext(1247 kB)315 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1247 kBChecksumma SHA-512
82cba1f13567d5303dabd02ec6690c29c618b01a7f3957e50c2ea3e07bc1c3dd00959a45a77d22b73a7b786c37ba99221bf57c4568d8113766e96c831ffcf6ad
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Andersson, LinusClaeson, Anna-SaraLind, NinaNordin, Steven

Sök vidare i DiVA

Av författaren/redaktören
Andersson, LinusClaeson, Anna-SaraLind, NinaNordin, Steven
Av organisationen
Institutionen för psykologi
I samma tidskrift
BMJ Open
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologiPsykologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 315 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 654 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf