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Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Department of Occupational and Public Health Sciences, University of Gävle, Sweden.
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
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2017 (Engelska)Ingår i: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 7, nr 2, artikel-id e013879Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: To investigate the pathophysiological pathways leading to symptoms elicitation in multiple chemical sensitivity (MCS) by comparing gene expression in MCS participants and healthy controls before and after a chemical exposure optimised to cause symptoms among MCS participants. The first hypothesis was that unexposed and symptom=-free MCS participants have similar gene expression patterns to controls and a second hypothesis that MCS participants can be separated from controls based on differential gene expression upon a controlled n=-butanol exposure.

Design: Participants were exposed to 3.7 ppm n-butanol while seated in a windowed exposure chamber for 60 min. A total of 26 genes involved in biochemical pathways found in the literature have been proposed to play a role in the pathogenesis of MCS and other functional somatic syndromes were selected. Expression levels were compared between MCS and controls before, within 15 min after being exposed to and 4 hours after the exposure.

Settings: Participants suffering from MCS and healthy controls were recruited through advertisement at public places and in a local newspaper.

Participants: 36 participants who considered themselves sensitive were prescreened for eligibility. 18 sensitive persons fulfilling the criteria for MCS were enrolled together with 18 healthy controls.

Outcome measures: 17 genes showed sufficient transcriptional level for analysis. Group comparisons were conducted for each gene at the 3 times points and for the computed area under the curve (AUC) expression levels.

Results: MCS participants and controls displayed similar gene expression levels both at baseline and after the exposure and the computed AUC values were likewise comparable between the 2 groups. The intragroup variation in expression levels among MCS participants was noticeably greater than the controls.

Conclusions: MCS participants and controls have similar gene expression levels at baseline and it was not possible to separate MCS participants from controls based on gene expression measured after the exposure.

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2017. Vol. 7, nr 2, artikel-id e013879
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Psykologi
Identifikatorer
URN: urn:nbn:se:umu:diva-133669DOI: 10.1136/bmjopen-2016-013879ISI: 000397872400106PubMedID: 28232466OAI: oai:DiVA.org:umu-133669DiVA, id: diva2:1090769
Tillgänglig från: 2017-04-25 Skapad: 2017-04-25 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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Andersson, LinusClaeson, Anna-SaraLind, NinaNordin, Steven

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Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologiPsykologi

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