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Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs
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2017 (Engelska)Ingår i: Nature Microbiology, E-ISSN 2058-5276, Vol. 2, nr 1, artikel-id 16189Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Helicobacter pylori specifically colonizes the human gastric epithelium and is the major causative agent for ulcer disease and gastric cancer development. Here, we identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of H. pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. HopQ-CEACAM binding is glycan-independent and targeted to the N-domain. H. pylori binding induces CEACAM1-mediated signalling, and the HopQ-CEACAM1 interaction enables translocation of the virulence factor CagA into host cells and enhances the release of pro-inflammatory mediators such as interleukin-8. Based on the crystal structure of HopQ, we found that a beta-hairpin insertion (HopQ-ID) in HopQ's extracellular 3+4 helix bundle domain is important for CEACAM binding. A peptide derived from this domain competitively inhibits HopQ-mediated activation of the Cag virulence pathway, as genetic or antibody-mediated abrogation of the HopQ function shows. Together, our data suggest the HopQ-CEACAM1 interaction to be a potentially promising novel therapeutic target to combat H. pylori-associated diseases.

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NATURE PUBLISHING GROUP , 2017. Vol. 2, nr 1, artikel-id 16189
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Immunologi inom det medicinska området Mikrobiologi inom det medicinska området
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URN: urn:nbn:se:umu:diva-133381DOI: 10.1038/nmicrobiol.2016.189ISI: 000396366300008PubMedID: 27748768OAI: oai:DiVA.org:umu-133381DiVA, id: diva2:1090903
Tillgänglig från: 2017-04-25 Skapad: 2017-04-25 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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Schmidt, Alexej

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