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Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för tillämpad fysik och elektronik. Swedish Defence Research Agency, 906 21 Umeå, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Cell Host and Microbe, ISSN 1931-3128, E-ISSN 1934-6069, Vol. 21, nr 3, s. 376-389Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.

sted, utgiver, år, opplag, sider
CELL PRESS , 2017. Vol. 21, nr 3, s. 376-389
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-132788DOI: 10.1016/j.chom.2017.02.013ISI: 000396375600023PubMedID: 28279347OAI: oai:DiVA.org:umu-132788DiVA, id: diva2:1094962
Tilgjengelig fra: 2017-05-11 Laget: 2017-05-11 Sist oppdatert: 2020-04-08bibliografisk kontrollert
Inngår i avhandling
1. Multifaceted adaptation in adherence by the gastric pathogen Helicobacter pylori
Åpne denne publikasjonen i ny fane eller vindu >>Multifaceted adaptation in adherence by the gastric pathogen Helicobacter pylori
2017 (engelsk)Licentiatavhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Umeå: Umeå Universitet, 2017. s. 41
Emneord
H. pylori, BabA, oligomerization, Leb, recombination, mutation, adherence, pH-sensitive, pH-resistant
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-137462 (URN)978-91-7601-733-3 (ISBN)
Tilgjengelig fra: 2017-07-05 Laget: 2017-07-03 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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Björnham, OscarChernov, Yevgen A.Gideonsson, PärHenriksson, SaraMendez, MelissaShevtsova, AnnaAisenbrey, ChristopherBylund, GöranSchmidt, AlexejÅberg, AnnaBrännström, KristofferRakhimova, LenaHofer, AndersÅden, JörgenMorozova-Roche, Ludmilla A.Olofsson, AndersGröbner, GerhardEsberg, AndersStrömberg, NicklasLandström, MaréneSchedin, StaffanArnqvist, AnnaBoren, Thomas
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