Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Levels of oxylipins, endocannabinoids and related lipids in plasma before and after low-level exposure to acrolein in healthy individuals and individuals with chemical intolerance
Umeå University, Faculty of Social Sciences, Department of Psychology.ORCID iD: 0000-0001-5026-4934
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
Show others and affiliations
2017 (English)In: Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, E-ISSN 1532-2823, Vol. 121, p. 60-67Article in journal (Refereed) Published
Abstract [en]

Oxylipins and endocannabinoids play important biological roles, including effects upon inflammation. It is not known whether the circulating levels of these lipids are affected by inhalation of the environmental pollutant acrolein. In the present study, we have investigated the consequences of low-level exposure to acrolein on oxylipin, endocannabinoid and related lipid levels in the plasma of healthy individuals and individuals with chemical intolerance (CI), an affliction with a suggested inflammatory origin. Participants were exposed twice (60 min) to heptane and a mixture of heptane and acrolein. Blood samples were collected before exposure, after and 24 h post-exposure. There were no overt effects of acrolein exposure on the oxylipin lipidome or endocannibinoids detectable in the bloodstream at the time points investigated. No relationship between basal levels or levels after exposure to acrolein and CI could be identified. This implicates a minor role of inflammatory mediators on the systemic level in CI.

Place, publisher, year, edition, pages
2017. Vol. 121, p. 60-67
Keywords [en]
Oxylipins, Endocannabinoids, Plasma, Human exposure, Acrolein, Chemical intolerance
National Category
Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:umu:diva-136786DOI: 10.1016/j.plefa.2017.06.004ISI: 000405763500009Scopus ID: 2-s2.0-85021183358OAI: oai:DiVA.org:umu-136786DiVA, id: diva2:1113757
Funder
Swedish Research Council Formas, 2010-1401Available from: 2017-06-22 Created: 2017-06-22 Last updated: 2023-03-23Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records

Claeson, Anna-SaraGouveia-Figueira, SandraHäggström, JennyFowler, Christopher J.Nording, Malin L.

Search in DiVA

By author/editor
Claeson, Anna-SaraGouveia-Figueira, SandraHäggström, JennyFowler, Christopher J.Nording, Malin L.
By organisation
Department of PsychologyDepartment of ChemistryStatisticsPharmacology
In the same journal
Prostaglandins, Leukotrienes and Essential Fatty Acids
Occupational Health and Environmental Health

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 582 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf