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Levels of oxylipins, endocannabinoids and related lipids in plasma before and after low-level exposure to acrolein in healthy individuals and individuals with chemical intolerance
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.ORCID-id: 0000-0001-5026-4934
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Samhällsvetenskapliga fakulteten, Handelshögskolan vid Umeå universitet, Statistik.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Farmakologi.
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2017 (engelsk)Inngår i: Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, E-ISSN 1532-2823, Vol. 121, s. 60-67Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Oxylipins and endocannabinoids play important biological roles, including effects upon inflammation. It is not known whether the circulating levels of these lipids are affected by inhalation of the environmental pollutant acrolein. In the present study, we have investigated the consequences of low-level exposure to acrolein on oxylipin, endocannabinoid and related lipid levels in the plasma of healthy individuals and individuals with chemical intolerance (CI), an affliction with a suggested inflammatory origin. Participants were exposed twice (60 min) to heptane and a mixture of heptane and acrolein. Blood samples were collected before exposure, after and 24 h post-exposure. There were no overt effects of acrolein exposure on the oxylipin lipidome or endocannibinoids detectable in the bloodstream at the time points investigated. No relationship between basal levels or levels after exposure to acrolein and CI could be identified. This implicates a minor role of inflammatory mediators on the systemic level in CI.

sted, utgiver, år, opplag, sider
2017. Vol. 121, s. 60-67
Emneord [en]
Oxylipins, Endocannabinoids, Plasma, Human exposure, Acrolein, Chemical intolerance
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Identifikatorer
URN: urn:nbn:se:umu:diva-136786DOI: 10.1016/j.plefa.2017.06.004ISI: 000405763500009OAI: oai:DiVA.org:umu-136786DiVA, id: diva2:1113757
Forskningsfinansiär
Swedish Research Council Formas, 2010-1401Tilgjengelig fra: 2017-06-22 Laget: 2017-06-22 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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Claeson, Anna-SaraGouveia-Figueira, SandraHäggström, JennyFowler, Christopher J.Nording, Malin L.

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