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Telomere length, allergies and risk of Glioma
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
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2017 (English)In: Neuro-Oncology, ISSN 1522-8517, E-ISSN 1523-5866, Vol. 19, no S3, p. 23-23, article id P01.03Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Background: In glioma, a malignant brain tumour with poor prognosis, the etiology is largely unkown. Rare inherited syndromes, and high doses of ionising radiation are associated with increased risk of glioma. Common genetic variants have been associated with risk of glioma, and familial glioma have been associated with genetic variants in genes functionally important in telomere regulation (e.g. RTEL, TERT and POT1). The association between telomere length and risk of cancer is complex and seems to be tumour type dependent. Patients with asthma have significantly shorter telomeres than those of control subjects, and a protective effect has been observed with an inverse association with allergies and asthma and glioma risk. 

Methods: We investigated population based glioma case-control series (431 cases and 672 controls) from Sweden at diagnosis with a quantitative PCR method for relative leukocyte telomere length measured in blood confirming with direct measurement of the association between telomere length and risk of glioma. We also explored the relationship between, age, gender, allergies and asthma, as these are established factors associated both with telomere length and glioma.

Results: Longer relative leukocyte telomere length was significantly associated with increased risk of glioma, adjusting for age and gender (OR=2.23, CI: 1.11–4.47). As expected, for patients with allergies there was a protective effect with an inverse association with glioma risk, adjusting for age and gender (OR=0.64, CI; 0.48–0.85). Nevertheless, when analysing specific types of allergy, eczema (OR=0.66, CI; 0.41–1.08) and water eyes (OR=0.52, CI; 0.31–0.88) appeared to be more protective against glioma, compared to asthma (OR=0.92, CI; 0.59–1.41), and respiratory symptoms (OR=1.14, CI; 0.71–1.84) which showed no protective effect against glioma. Additionally adjusting for allergies did not markedly change the OR between relative leukocyte telomere length and glioma risk, indicating that the protective effect having allergies seems not to be coupled to telomere length. Conclusions: The adverse association of longer telomere and risk of glioma displays the complexity in understanding the biological role of telomere length and risk of developing cancer.

Place, publisher, year, edition, pages
Oxford University Press, 2017. Vol. 19, no S3, p. 23-23, article id P01.03
Keywords [en]
polymerase chain reaction, hypersensitivity, asthma, brain tumors, cancer, eczema, genes, glioma, leukocytes, signs and symptoms, respiratory, telomere, diagnosis, eye, genetics, neoplasms, radiation, ionizing, gender, cancer risk, causality
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-136984DOI: 10.1093/neuonc/nox036.079ISI: 000402732900081OAI: oai:DiVA.org:umu-136984DiVA, id: diva2:1118374
Conference
5th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology-Societies (WFNOS), Zurich, Switzerland, May 4-7, 2017
Note

Volume 19, Supplement 3, 1 May 2017

5th Quadrennial Meeting of the World Federation of Neuro-Oncology Societies (WFNOS), May 4-7, 2017, Zurich, Switzerland

Available from: 2017-06-30 Created: 2017-06-30 Last updated: 2020-03-12Bibliographically approved

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Andersson, UlrikaDegerman, SofieDahlin, AnnaBrannstrom, ThomasRoos, Göran

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