Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study
Show others and affiliations
2017 (English)In: BMC Medicine, E-ISSN 1741-7015, Vol. 15, article id 115Article in journal (Refereed) Published
Abstract [en]

Background: The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not differentiated between high-grade or advanced stage tumours, but rather have assessed risk with a combined category of aggressive disease. We investigated the association of height and adiposity with incidence of and death from prostate cancer in 141,896 men in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Multivariable-adjusted Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average of 13.9 years of follow-up, there were 7024 incident prostate cancers and 934 prostate cancer deaths. Results: Height was not associated with total prostate cancer risk. Subgroup analyses showed heterogeneity in the association with height by tumour grade (P-heterogeneity = 0.002), with a positive association with risk for high-grade but not low-intermediate-grade disease (HR for high-grade disease tallest versus shortest fifth of height, 1.54; 95% CI, 1.18-2.03). Greater height was also associated with a higher risk for prostate cancer death (HR = 1.43, 1.14-1.80). Body mass index (BMI) was significantly inversely associated with total prostate cancer, but there was evidence of heterogeneity by tumour grade (P-heterogeneity = 0.01; HR = 0.89, 0.79-0.99 for low-intermediate grade and HR = 1.32, 1.01-1.72 for high-grade prostate cancer) and stage (P-heterogeneity = 0.01; HR = 0.86, 0.75-0.99 for localised stage and HR = 1.11, 0.92-1.33 for advanced stage). BMI was positively associated with prostate cancer death (HR = 1.35, 1.09-1.68). The results for waist circumference were generally similar to those for BMI, but the associations were slightly stronger for high-grade (HR = 1.43, 1.07-1.92) and fatal prostate cancer (HR = 1.55, 1.23-1.96). Conclusions: The findings from this large prospective study show that men who are taller and who have greater adiposity have an elevated risk of high-grade prostate cancer and prostate cancer death.

Place, publisher, year, edition, pages
BioMed Central, 2017. Vol. 15, article id 115
Keywords [en]
Adiposity, Obesity, Height, Prostate cancer, Cohort study, Tumour characteristics, High grade
National Category
Cancer and Oncology Urology and Nephrology Pathobiology
Identifiers
URN: urn:nbn:se:umu:diva-137940DOI: 10.1186/s12916-017-0876-7ISI: 000405316800001Scopus ID: 2-s2.0-85023169131OAI: oai:DiVA.org:umu-137940DiVA, id: diva2:1129536
Available from: 2017-08-04 Created: 2017-08-04 Last updated: 2023-03-24Bibliographically approved

Open Access in DiVA

fulltext(867 kB)260 downloads
File information
File name FULLTEXT01.pdfFile size 867 kBChecksum SHA-512
d920895c52abe2662b0d859adb29052e55b2ca0a14b69eeeb79da467adda83466db66779cfd17d644f06fde774dbd4eab7c4d574fb36b997daf2587f76b272e5
Type fulltextMimetype application/pdf

Other links

Publisher's full textScopus

Authority records

Stattin, PärHäggström, Christel

Search in DiVA

By author/editor
Stattin, PärHäggström, Christel
By organisation
Urology and AndrologyDepartment of Biobank Research
In the same journal
BMC Medicine
Cancer and OncologyUrology and NephrologyPathobiology

Search outside of DiVA

GoogleGoogle Scholar
Total: 260 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 913 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf