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Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case-control study in the Northern Sweden Maternity Cohort
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
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2017 (Engelska)Ingår i: Breast Cancer Research, ISSN 1465-5411, E-ISSN 1465-542X, Vol. 19, artikel-id 82Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones.

Methods: We conducted a nested case–control study in the Northern Sweden Maternity Cohort (1975–2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection). Estrogen receptor (ER) and progesterone receptor (PR) status was available for all cases; androgen receptor (AR) data were available for 41% of cases (n = 92). Sex steroids were quantified by high-performance liquid chromatography tandem mass spectrometry. Odds ratios (ORs) and 95% confidence intervals were estimated using conditional logistic regression.

Results: Higher concentrations of circulating progesterone in early pregnancy were inversely associated with ER+/PR+ breast cancer risk (ORlog2: 0.64 (0.41–1.00)). Higher testosterone was positively associated with ER+/PR+ disease risk (ORlog2: 1.57 (1.13–2.18)). Early pregnancy estrogens were not associated with risk, except for relatively high estradiol in the context of low progesterone (split at median, relative to low concentrations of both; OR: 1.87 (1.11–3.16)). None of the investigated hormones were associated with ER–/PR– disease, or with AR+ or AR+/ER+/PR+ disease.

Conclusions: Consistent with experimental models, high progesterone in early pregnancy was associated with lower risk of ER+/PR+ breast cancer in the mother. High circulating testosterone in early pregnancy, which likely reflects nonpregnant premenopausal exposure, was associated with higher risk of ER+/PR+ disease.

Ort, förlag, år, upplaga, sidor
2017. Vol. 19, artikel-id 82
Nyckelord [en]
Endogenous hormones, Early pregnancy, Breast cancer, Sex steroids
Nationell ämneskategori
Cancer och onkologi Reproduktionsmedicin och gynekologi
Identifikatorer
URN: urn:nbn:se:umu:diva-138032DOI: 10.1186/s13058-017-0876-8ISI: 000405797900001OAI: oai:DiVA.org:umu-138032DiVA, id: diva2:1133620
Tillgänglig från: 2017-08-16 Skapad: 2017-08-16 Senast uppdaterad: 2018-08-31Bibliografiskt granskad

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Tolockiene, EgleLakso, Hans-ÅkeHallmans, GöranGrankvist, KjellLundin, Eva

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