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Alterations in white matter microstructure are associated with goal-directed upper-limb movement segmentation in children born extremely preterm
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Fysioterapi.
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Diagnostisk radiologi.
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2017 (Engelska)Ingår i: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 38, nr 10, s. 5051-5068Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Altered white matter microstructure is commonly found in children born preterm (PT), especially those born at an extremely low gestational age (GA). These children also commonly show disturbed motor function. This study explores the relation between white matter alterations and upperlimb movement segmentation in 41 children born PT (19 girls), and 41 children born at term (18 girls) at 8 years. The PT group was subdivided into extremely PT (E-PT; GA = 25–27 weeks, N = 10), very PT (V-PT; GA = 28–32 weeks, N = 13), and moderately PT (M-PT; GA = 33–35 weeks, N = 18). Arm/hand preference (preferred/non-preferred) was determined through object interactions and the brain hemispheres were designated accordingly. White matter alterations were assessed using diffusion tensor imaging in nine areas, and movement segmentation of the body-parts head, shoulder, elbow, and wrist were registered during a unimanual goal-directed task. Increased movement segmentation was demonstrated consistently on the preferred side in the E-PT group compared with the term born group. Also compared with the term born peers, the E-PT group demonstrated reduced fractional anisotropy (FA) in the cerebral peduncle (targeting the corticospinal tract) in the hemisphere on the non-preferred side and in the splenium of corpus callosum. In contrast, in the anterior internal capsule on the preferred side, the E-PT group had increased FA. Lower FA in the cerebral peduncle, but higher FA in the anterior internal capsule, was associated with increased movement segmentation across body-parts in a contralateral manner. The results suggest that impaired development of sensorimotor tracts in E-PT children could explain a sub-optimal spatiotemporal organization of upper-limb movements.

Ort, förlag, år, upplaga, sidor
Hoboken: Wiley-Blackwell, 2017. Vol. 38, nr 10, s. 5051-5068
Nyckelord [en]
diffusion tensor imaging, anisotropy, sensorimotor, corticospinal, internal capsule, laterality
Nationell ämneskategori
Psykologi
Forskningsämne
radiologi; psykologi; pediatrik
Identifikatorer
URN: urn:nbn:se:umu:diva-139528DOI: 10.1002/hbm.23714ISI: 000417002000017PubMedID: 28685893OAI: oai:DiVA.org:umu-139528DiVA, id: diva2:1141721
Forskningsfinansiär
Vetenskapsrådet, 2011-179Tillgänglig från: 2017-09-15 Skapad: 2017-09-15 Senast uppdaterad: 2019-01-08Bibliografiskt granskad

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Lenfeldt, NiklasJohansson, Anna-MariaDomellöf, ErikRiklund, KatrineRönnqvist, Louise

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Lenfeldt, NiklasJohansson, Anna-MariaDomellöf, ErikRiklund, KatrineRönnqvist, Louise
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Klinisk neurovetenskapInstitutionen för psykologiFysioterapiDiagnostisk radiologi
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