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Using a spontaneous profile rather than stimulation test makes the KIGS idiopathic growth hormone deficiency model more accessible for clinicians
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.ORCID-id: 0000-0002-5456-2514
2017 (engelsk)Inngår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, nr 9, s. 1481-1486Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Aim: Children treated with a growth hormone (GH) for idiopathic growth hormone deficiency (IGHD) may be monitored with the first-year prediction model from the Pfizer International Growth Database (KIGS) using auxology, age, GH dose and the maximum GH concentration from a stimulation test (GH(max)stim). We tested the hypothesis that using a 12-hour spontaneous profile (GH(max)12h) would be as accurate. Methods: We studied 98 prepubertal Swedish children (78boys) aged2-12 years enrolled in KIGS. The first-year growth was predicted using the GH(max) from the GHprofile and a stimulation test, and both of these were compared separately with the observed growth response. Results: The increased height observed in the first year was 0.74 standard deviation scores (SDS), and the studentised residuals for the predicted and observed growth with GH(max)stim (-0.16 SDS) and GH(max)12h (-0.22) were similar. Individual predictions calculated with stimulated or spontaneous GH(max) showed a significant correlation (r = 0.80). Conclusion: We validated the KIGS IGHD prediction model and found that the stimulated GH(max) peak can be reliably replaced by the GH(max) 12h with similar accuracy. This makes the model more accessible for clinicians, who can then provide realistic expectations for the growth response during the first year of treatment.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2017. Vol. 106, nr 9, s. 1481-1486
Emneord [en]
Growth hormone treatment, Growth response, Idiopathic growth hormone deficiency, Prediction del, Short stature
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Identifikatorer
URN: urn:nbn:se:umu:diva-139811DOI: 10.1111/apa.13932ISI: 000409343900018PubMedID: 28543706OAI: oai:DiVA.org:umu-139811DiVA, id: diva2:1144547
Tilgjengelig fra: 2017-09-26 Laget: 2017-09-26 Sist oppdatert: 2019-04-01bibliografisk kontrollert

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