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The N6-Methyladenosine RNA modification in pluripotency and reprogramming
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
2017 (English)In: Current Opinion in Genetics and Development, ISSN 0959-437X, E-ISSN 1879-0380, Vol. 46, p. 77-82Article, review/survey (Refereed) Published
Abstract [en]

Chemical modifications of RNA provide a direct and rapid way to manipulate the existing transcriptome, allowing rapid responses to the changing environment further enriching the regulatory capacity of RNA. N-6-Methyladenosine(m(6)A) has been identified as the most abundant internal modification of messenger RNA in eukaryotes, linking external stimuli to an intricate network of transcriptional, post-transcriptional and translational processes. M(6)A modification affects a broad spectrum of cellular functions, including maintenance of the pluripotency of embryonic stem cells (ESCs) and the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). In this review, we summarize the most recent findings on m(6)A modification with special focus on the different studies describing how m(6)A is implicated in ESC self-renewal, cell fate specification and iPSC generation.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 46, p. 77-82
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:umu:diva-140886DOI: 10.1016/j.gde.2017.06.006ISI: 000411955300011PubMedID: 28683341OAI: oai:DiVA.org:umu-140886DiVA, id: diva2:1158166
Available from: 2017-11-17 Created: 2017-11-17 Last updated: 2019-05-10Bibliographically approved

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Aguilo, Francesca

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