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PrimPol is required for replication reinitiation after mtDNA damage
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2017 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 114, no 43, p. 11398-11403Article in journal (Refereed) Published
Abstract [en]

Eukaryotic PrimPol is a recently discovered DNA-dependent DNA primase and translesion synthesis DNA polymerase found in the nucleus and mitochondria. Although PrimPol has been shown to be required for repriming of stalled replication forks in the nucleus, its role in mitochondria has remained unresolved. Here we demonstrate in vivo and in vitro that PrimPol can reinitiate stalled mtDNA replication and can prime mtDNA replication from nonconventional origins. Our results not only help in the understanding of how mitochondria cope with replicative stress but can also explain some controversial features of the lagging-strand replication.

Place, publisher, year, edition, pages
National Academy of Sciences , 2017. Vol. 114, no 43, p. 11398-11403
Keywords [en]
DNA repair, fork rescue, mtDNA damage, mtDNA replication
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-141811DOI: 10.1073/pnas.1705367114ISI: 000413520700056PubMedID: 29073063OAI: oai:DiVA.org:umu-141811DiVA, id: diva2:1160597
Available from: 2017-11-27 Created: 2017-11-27 Last updated: 2018-06-09Bibliographically approved

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Forslund, Josefin M. E.Pfeiffer, AnnikaStojkovič, GorazdAl-Furoukh, NatalieWanrooij, Sjoerd

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Forslund, Josefin M. E.Pfeiffer, AnnikaStojkovič, GorazdAl-Furoukh, NatalieWanrooij, Sjoerd
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Department of Medical Biochemistry and Biophysics
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Proceedings of the National Academy of Sciences of the United States of America
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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Citation style
  • apa
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