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PrimPol is required for replication reinitiation after mtDNA damage
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
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2017 (engelsk)Inngår i: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 114, nr 43, s. 11398-11403Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Eukaryotic PrimPol is a recently discovered DNA-dependent DNA primase and translesion synthesis DNA polymerase found in the nucleus and mitochondria. Although PrimPol has been shown to be required for repriming of stalled replication forks in the nucleus, its role in mitochondria has remained unresolved. Here we demonstrate in vivo and in vitro that PrimPol can reinitiate stalled mtDNA replication and can prime mtDNA replication from nonconventional origins. Our results not only help in the understanding of how mitochondria cope with replicative stress but can also explain some controversial features of the lagging-strand replication.

sted, utgiver, år, opplag, sider
National Academy of Sciences , 2017. Vol. 114, nr 43, s. 11398-11403
Emneord [en]
DNA repair, fork rescue, mtDNA damage, mtDNA replication
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-141811DOI: 10.1073/pnas.1705367114ISI: 000413520700056PubMedID: 29073063OAI: oai:DiVA.org:umu-141811DiVA, id: diva2:1160597
Tilgjengelig fra: 2017-11-27 Laget: 2017-11-27 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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Forslund, Josefin M. E.Pfeiffer, AnnikaStojkovič, GorazdAl-Furoukh, NatalieWanrooij, Sjoerd

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