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Comparison of T-2 Toxin and HT-2 Toxin Distributed in the Skeletal System with That in Other Tissues of Rats by Acute Toxicity Test
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2017 (English)In: Biomedical and environmental sciences, ISSN 0895-3988, E-ISSN 2214-0190, Vol. 30, no 11, p. 851-854Article in journal, Letter (Refereed) Published
Abstract [en]

Twelve healthy rats were divided into the T-2 toxin group receiving gavage of 1 mg/kg T-2 toxin and the control group receiving gavage of normal saline. Total relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system (thighbone, knee joints, and costal cartilage) were significantly higher than those in the heart, liver, and kidneys (P < 0.05). The relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system (thighbone and costal cartilage) were also significantly higher than those in the heart, liver, and kidneys. The rats administered T-2 toxin showed rapid metabolism compared with that in rats administered HT-2 toxin, and the metabolic conversion rates in the different tissues were 68.20%-90.70%.

Place, publisher, year, edition, pages
2017. Vol. 30, no 11, p. 851-854
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Physiology Medical Biotechnology
Identifiers
URN: urn:nbn:se:umu:diva-143735DOI: 10.3967/bes2017.115ISI: 000417851900010PubMedID: 29216964OAI: oai:DiVA.org:umu-143735DiVA, id: diva2:1171787
Available from: 2018-01-08 Created: 2018-01-08 Last updated: 2018-06-09Bibliographically approved

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Lammi, Mikko J.

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