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A biokinetic and dosimetric model for ionic indium in humans
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
2017 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 62, no 16, p. 6397-6407Article in journal (Refereed) Published
Abstract [en]

This paper reviews biokinetic data for ionic indium, and proposes a biokinetic model for systemic indium in adult humans. The development of parameter values focuses on human data and indium in the form of ionic indium(III), as indium chloride and indium arsenide. The model presented for systemic indium is defined by five different pools: plasma, bone marrow, liver, kidneys and other soft tissues. The model is based on two subsystems: one corresponding to indium bound to transferrin and one where indium is transported back to the plasma, binds to red blood cell transferrin and is then excreted through the kidneys to the urinary bladder. Absorbed doses to several organs and the effective dose are calculated for In-111- and In-113m-ions. The proposed biokinetic model is compared with previously published biokinetic indium models published by the ICRP. The absorbed doses are calculated using the ICRP/ICRU adult reference phantoms and the effective dose is estimated according to ICRP Publication 103. The effective doses for In-111 and In-113m are 0.25 mSv MBq(-1) and 0.013 mSv MBq(-1) respectively. The updated biokinetic and dosimetric models presented in this paper take into account human data and new animal data, which represent more detailed and presumably more accurate dosimetric data than that underlying previous models for indium.

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2017. Vol. 62, no 16, p. 6397-6407
Keywords [en]
biokinetic model, indium, absorbed dsoe, effective dose
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:umu:diva-145625DOI: 10.1088/1361-6560/aa779fISI: 000425825900003PubMedID: 28726676OAI: oai:DiVA.org:umu-145625DiVA, id: diva2:1190596
Available from: 2018-03-15 Created: 2018-03-15 Last updated: 2018-06-09Bibliographically approved

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Johansson, Lennart

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