umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Plasma miRNA can detect colorectal cancer, but how early?
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.ORCID-id: 0000-0002-9692-101x
Vise andre og tillknytning
2018 (engelsk)Inngår i: Cancer Medicine, ISSN 2045-7634, E-ISSN 2045-7634, Vol. 7, nr 5, s. 1697-1705Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Colorectal cancer (CRC) is a major cause of deaths worldwide but has a good prognosis if detected early. The need for efficient, preferable non‐ or minimally invasive, inexpensive screening tools is therefore critical. We analyzed 12 miRNAs in pre‐ and postdiagnostic plasma samples to evaluate their potential as CRC screening markers. We used a unique study design with two overlapping cohorts, allowing analysis of pre‐ and postdiagnostic samples from 58 patients with CRC and matched healthy controls. Plasma concentrations of miR‐15b, ‐16, ‐18a, ‐19a, 21, ‐22, ‐25, ‐26a, ‐29c, ‐142‐5p, ‐150, and ‐192 were measured by semi‐quantitative real‐time PCR. Concentrations of miR‐18a, ‐21, ‐22, and ‐25 in plasma from patients with CRC were significantly altered compared to healthy controls. Combined as a multimarker panel, they detected CRC with an AUC of 0.93. Furthermore, levels of these three miRNAs also showed different levels in the prediagnostic case samples close to diagnosis. Only miR‐21‐levels were elevated several years before diagnosis. Plasma levels of miR‐18a, ‐21, ‐22, and ‐25 show promise as screening biomarkers for CRC. However, based on our unique analysis of prediagnostic and postdiagnostic samples from the same patients, we conclude that circulating miRNAs elevated at diagnosis may not automatically be suitable for CRC screening, if the increase occurs too close to clinical diagnosis.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2018. Vol. 7, nr 5, s. 1697-1705
Emneord [en]
Colorectal cancer, early detection, plasma miRNA
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-146758DOI: 10.1002/cam4.1398ISI: 000431972900011PubMedID: 29573205Scopus ID: 2-s2.0-85044281770OAI: oai:DiVA.org:umu-146758DiVA, id: diva2:1198841
Tilgjengelig fra: 2018-04-19 Laget: 2018-04-19 Sist oppdatert: 2018-06-13bibliografisk kontrollert

Open Access i DiVA

fulltext(313 kB)90 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 313 kBChecksum SHA-512
006d9fd56c94b8f97c73a6cb2f3d939dc4ae474fdde18adad20fd388a66691168660f265d00dcbf553c4785a2325e852141601aeff1ad5034a3db9d2efffc826
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Personposter BETA

Wikberg, Maria L.Myte, RobinPalmqvist, Richardvan Guelpen, BethanyLjuslinder, Ingrid

Søk i DiVA

Av forfatter/redaktør
Wikberg, Maria L.Myte, RobinPalmqvist, Richardvan Guelpen, BethanyLjuslinder, Ingrid
Av organisasjonen
I samme tidsskrift
Cancer Medicine

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 90 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 233 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf