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Glycomics and Proteomics Approaches to Investigate Early Adenovirus-Host Cell Interactions
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi. Umeå universitet, Medicinska fakulteten, Molekylär Infektionsmedicin, Sverige (MIMS).
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi. Umeå universitet, Medicinska fakulteten, Molekylär Infektionsmedicin, Sverige (MIMS).
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi. Umeå universitet, Medicinska fakulteten, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM). Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany. (Gisa Gerold)
2018 (engelsk)Inngår i: Journal of Molecular Biology, ISSN 0022-2836, E-ISSN 1089-8638, Vol. 430, nr 13, s. 1863-1882Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Adenoviruses as most viruses rely on glycan and protein interactions to attach to and enter susceptible host cells. The Adenoviridae family comprises more than 80 human types and they differ in their attachment factor and receptor usage, which likely contributes to the diverse tropism of the different types. In the past years, methods to systematically identify glycan and protein interactions have advanced. In particular sensitivity, speed and coverage of mass spectrometric analyses allow for high-throughput identification of glycans and peptides separated by liquid chromatography. Also, developments in glycan microarray technologies have led to targeted, high-throughput screening and identification of glycan-based receptors. The mapping of cell surface interactions of the diverse adenovirus types has implications for cell, tissue, and species tropism as well as drug development. Here we review known adenovirus interactions with glycan- and protein-based receptors, as well as glycomics and proteomics strategies to identify yet elusive virus receptors and attachment factors. We finally discuss challenges, bottlenecks, and future research directions in the field of non-enveloped virus entry into host cells.

sted, utgiver, år, opplag, sider
2018. Vol. 430, nr 13, s. 1863-1882
Emneord [en]
adenovirus, glycomis, host cell interactions, proteomics, virus entry
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-148152DOI: 10.1016/j.jmb.2018.04.039ISI: 000436224800004PubMedID: 29746851Scopus ID: 2-s2.0-85047296623OAI: oai:DiVA.org:umu-148152DiVA, id: diva2:1210759
Tilgjengelig fra: 2018-05-29 Laget: 2018-05-29 Sist oppdatert: 2018-09-28bibliografisk kontrollert

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