umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Hepatitis C virus NS5B polymerase primes innate immune signaling
Institute of Experimental Virology Twincore – Center for Experimental and Clinical Infectious Disease Research Hannover, Germany. (Gisa Gerold)
2013 (engelsk)Inngår i: Hepatology, ISSN 0270-9139, E-ISSN 1527-3350, Vol. 57, nr 3, s. 1275-1277Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Innate immunity controls pathogen replication and spread. Yet, certain pathogens, such as Hepatitis C Virus (HCV), escape immune elimination and establish persistent infections that promote chronic inflammation and related diseases. Whereas HCV regulatory proteins that attenuate antiviral responses are known, those that promote inflammation and liver injury remain to be identified. Here, we show that transient expression of HCV RNA-dependent RNA polymerase (RdRp), NS5B, in mouse liver and human hepatocytes results in production of small RNA species that activate innate immune signaling via TBK1-IRF3 and NF-kappa B and induce cytokine production, including type I interferons (IFN) and IL-6. NS5B-expression also results in liver damage.

sted, utgiver, år, opplag, sider
Hoboken: Wiley-Blackwell, 2013. Vol. 57, nr 3, s. 1275-1277
Emneord [en]
de-novo initiation, RIG-I, replication complex, adapter protein, RNA synthesis, infection, pathway
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-148167DOI: 10.1002/hep.26201ISI: 000315644200047PubMedID: 23426794OAI: oai:DiVA.org:umu-148167DiVA, id: diva2:1210806
Tilgjengelig fra: 2018-05-29 Laget: 2018-05-29 Sist oppdatert: 2018-09-05bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Gerold, Gisa

Søk i DiVA

Av forfatter/redaktør
Gerold, Gisa
I samme tidsskrift
Hepatology

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 209 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf