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Characterization of a canine homolog of hepatitis C virus
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065. (Gisa Gerold)
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2011 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 108, no 28, p. 11608-11613Article in journal (Refereed) Published
Abstract [en]

An estimated 3% of the world's population is chronically infected with hepatitis C virus (HCV). Although HCV was discovered more than 20 y ago, its origin remains obscure largely because no closely related animal virus homolog has been identified; furthermore, efforts to understand HCV pathogenesis have been hampered by the absence of animal models other than chimpanzees for human disease. Here we report the identification in domestic dogs of a nonprimate hepacivirus. Comparative phylogenetic analysis of the canine hepacivirus (CHV) confirmed it to be the most genetically similar animal virus homolog of HCV. Bayesian Markov chains Monte Carlo and associated time to most recent common ancestor analyses suggest a mean recent divergence time of CHV and HCV clades within the past 500-1,000 y, well after the domestication of canines. The discovery of CHV may provide new insights into the origin and evolution of HCV and a tractable model system with which to probe the pathogenesis, prevention, and treatment of diseases caused by hepacivirus infection.

Place, publisher, year, edition, pages
National Academy of Sciences , 2011. Vol. 108, no 28, p. 11608-11613
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-148174DOI: 10.1073/pnas.1101794108ISI: 000292635200062PubMedID: 21610165OAI: oai:DiVA.org:umu-148174DiVA, id: diva2:1210814
Funder
NIH (National Institute of Health), AI090196NIH (National Institute of Health), AI079231NIH (National Institute of Health), AI57158NIH (National Institute of Health), AI070411NIH (National Institute of Health), AI090055NIH (National Institute of Health), AI072613NIH (National Institute of Health), EY017404Available from: 2018-05-29 Created: 2018-05-29 Last updated: 2019-01-29Bibliographically approved

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CiteExportLink to record
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